The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

Publications HAL


Journal articles

Hassan Abdoul-Carime, Janina Kopyra. Reactions in CCl4 films deposited onto a cold gold substrate induced by charge transfer vs (0–5) eV free electrons. Chem.Phys.Lett., 2023, 810, pp.140182. ⟨10.1016/j.cplett.2022.140182⟩. ⟨hal-03865746⟩

Anne-Sophie Wozny, Claire Rodriguez-Lafrasse. The ‘stealth-bomber’ paradigm for deciphering the tumour response to carbon-ion irradiation. British Journal of Cancer, In press, ⟨10.1038/s41416-022-02117-6⟩. ⟨hal-03939645⟩

B. Ananthanarayan, Souvik Bera, S. Friot, O. Marichev, Tanay Pathak. On the evaluation of the Appell F_2 double hypergeometric function. Comput.Phys.Commun., 2023, 284, pp.108589. ⟨hal-03448554⟩

Florence Charlieux, Hassan Abdoul‐carime. Processes Induced by Electrons at Sub‐Ionization Energies Studied by the Correlated Ions‐(Ions/Neutrals) Mass Spectrometry. ChemPhysChem, 2023, ⟨10.1002/cphc.202200722⟩. ⟨hal-03960242⟩


Journal articles

Yasmine Ali, Caterina Monini, Etienne Russeil, Jean Michel LĂ©tang, Etienne Testa, et al.. Estimate of the Biological Dose in Hadrontherapy Using GATE. Cancers, 2022, 14 (7), pp.1667. ⟨10.3390/cancers14071667⟩. ⟨hal-03622514⟩

Hassan Abdoul-Carime, Guillaume Thiam, Franck Rabilloud, Florence Charlieux, Janina Kopyra. Chemistry in Acetonitrile–Water Films Induced by Slow (<15 eV) Electrons: Application to the Earth and Space Chemistry. ACS Earth and Space Chemistry, 2022, 6 (4), pp.1126-1132. ⟨10.1021/acsearthspacechem.2c00024⟩. ⟨hal-03620854⟩

Pierre Philouze, Arnaud Gauthier, Alexandra Lauret, CĂ©line MalĂ©sys, Giovanna Muggiolu, et al.. CD44, gamma-H2AX, and p-ATM Expressions in Short-Term Ex Vivo Culture of Tumour Slices Predict the Treatment Response in Patients with Oral Squamous Cell Carcinoma. International Journal of Molecular Sciences, 2022, 23 (2), ⟨10.3390/ijms23020877⟩. ⟨hal-03599302⟩

Carmen Villagrasa, Hans Rabus, Giorgio Baiocco, Yann Perrot, Alessio Parisi, et al.. Intercomparison of micro- and nanodosimetry Monte Carlo simulations: An approach to assess the influence of different cross-sections for low-energy electrons on the dispersion of results. Radiation Measurements, 2022, 150, pp.106675. ⟨10.1016/j.radmeas.2021.106675⟩. ⟨hal-03508915⟩

Paul Rocchi, Delphine Brichart-Vernos, François Lux, I. Morfin, Laurent David, et al.. A New Generation of Ultrasmall Nanoparticles Inducing Sensitization to Irradiation and Copper Depletion to Overcome Radioresistant and Invasive Cancers. Pharmaceutics, 2022, 14 (4), pp.814. ⟨10.3390/pharmaceutics14040814⟩. ⟨hal-03662053⟩

Nils Krah, Denis Dauvergne, Jean Michel LĂ©tang, Simon Rit, Etienne Testa. Relative stopping power resolution in time-of-flight proton CT. Physics in Medicine and Biology, 2022, 67 (16), pp.165004. ⟨10.1088/1361-6560/ac7191⟩. ⟨hal-03677847⟩

George Dedes, Jannis Dickmann, Valentina Giacometti, Simon Rit, Nils Krah, et al.. The role of Monte Carlo simulation in understanding the performance of proton computed tomography. Zeitschrift fur Medizinische Physik, 2022, 32, pp.23-38. ⟨10.1016/j.zemedi.2020.06.006⟩. ⟨hal-02920133⟩

Enrique Muñoz, A. Etxebeste, Denis Dauvergne, Jean Michel LĂ©tang, David Sarrut, et al.. Imaging of polychromatic sources through Compton spectral reconstruction. Physics in Medicine and Biology, 2022, 67 (19), pp.195017. ⟨10.1088/1361-6560/ac92b9⟩. ⟨hal-03808491⟩

Yasmine Ali, Lucas Auzel, Caterina Monini, Kateryna Kriachok, Jean Michel LĂ©tang, et al.. Monte Carlo simulations of nanodosimetry and radiolytic species production for monoenergetic proton and electron beams. Benchmarking of GEANT4‐DNA and LPCHEM codes. Medical Physics, 2022, 49 (5), pp.3457-3469. ⟨10.1002/mp.15609⟩. ⟨hal-03622534⟩

Nicolas MagnĂ©, Elisabeth Daguenet, Wafa Bouleftour, Laurine Conraux, Fabien Tinquaut, et al.. Impact of Radiation Therapy on Biological Parameters in Cancer Patients: Sub-analysis from the RIT Prospective Epidemiological Study. Cancer Investigation, 2022, ⟨10.1080/07357907.2022.2139838⟩. ⟨hal-03865012⟩

Magdalena Garbacz, Jan Gajewski, Marco Durante, Kamil Kisielewicz, Nils Krah, et al.. Quantification of biological range uncertainties in patients treated at the Krakow proton therapy centre. Radiation Oncology, 2022, 17 (1), pp.50. ⟨10.1186/s13014-022-02022-5⟩. ⟨hal-03615439⟩


Journal articles

Elodie A Courtois, Wafa Bouleftour, Jean-Baptiste Guy, Safa Louati, RenĂ©-Jean Bensadoun, et al.. Mechanisms of PhotoBioModulation (PBM) focused on oral mucositis prevention and treatment: a scoping review. BMC Oral Health, 2021, 21 (1), ⟨10.1186/s12903-021-01574-4⟩. ⟨hal-03326520⟩

Magdalena Garbacz, Francesco Giuseppe Cordoni, Marco Durante, Jan Gajewski, Kamil Kisielewicz, et al.. Study of relationship between dose, LET and the risk of brain necrosis after proton therapy for skull base tumors. Radiotherapy & Oncology, 2021, 163, pp.143-149. ⟨10.1016/j.radonc.2021.08.015⟩. ⟨hal-03346790⟩

Anne-Sophie Wozny, Arnaud Gauthier, Gersende Alphonse, CĂ©line MalĂ©sys, Virginie Varoclier, et al.. Involvement of HIF-1α in the Detection, Signaling, and Repair of DNA Double-Strand Breaks after Photon and Carbon-Ion Irradiation. Cancers, 2021, 13 (15), pp.3833. ⟨10.3390/cancers13153833⟩. ⟨hal-03326508⟩

Jean-Baptiste Guy, Sophie Espenel, Safa Louati, Arnaud Gauthier, Max-Adrien Garcia, et al.. Combining radiation to EGFR and Bcl-2 blockade: a new approach to target cancer stem cells in head and neck squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology, 2021, 147 (7), pp.1905-1916. ⟨10.1007/s00432-021-03593-8⟩. ⟨hal-03258241⟩

Jayde Livingstone, Denis Dauvergne, A. Etxebeste, Mattia Fontana, Marie-Laure Gallin-Martel, et al.. Influence of sub-nanosecond time of flight resolution for online range verification in proton therapy using the line-cone reconstruction in Compton imaging. Physics in Medicine and Biology, 2021, 66, pp.125012. ⟨10.1088/1361-6560/ac03cb⟩. ⟨hal-03257804⟩