Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENT MEMBERS:

NON-PERMANENT MEMBERS:

- DOCTORAL STUDENTS:
551 documents

  • Thomas Berger, Gersende Alphonse, Mario Alcocer-Avila, Caterina Monini, Charbel Koumeir, et al.. Response to Khodamoradi: Methodological clarifications regarding NanOx predictions in helium SOBP. Physics and Imaging in Radiation Oncology, 2026, 41, pp.101088. ⟨10.1016/j.phro.2026.101088⟩. ⟨hal-05784254⟩
  • Floriane Poignant, Victor Levrague, Mathieu Roccia, Ngoc Hoang Tran, SĂ©bastien Incerti, et al.. DNA decompaction enhances the formation of radiation-induced DNA double strand breaks and chromosome aberrations. Life Sciences in Space Research, 2026, 51, pp.45-55. ⟨10.1016/j.lssr.2025.10.006⟩. ⟨hal-05354503⟩
  • Gersende Alphonse, CĂ©line MalĂ©sys, Virginie Varoclier, SimonĂ© Bovio, Hamid Ladjal, et al.. CARBON IONS STIFFEN HNSCC CANCER STEM CELLS AND SUPPRESS POST-IRRADIATION MIGRATION AND INVASION COMPARED WITH PHOTONS. PTCOG 64, Jun 2026, Deauville, France. pp.101730, ⟨10.1016/j.ijpt.2026.101730⟩. ⟨hal-05801149⟩
  • Victor Levrague, Mario Alcocer Avila, Michael Beuve, Hamid Ladjal, Etienne Testa, et al.. In silico study of cell survival and TCP in targeted alpha therapy: impact of radionuclide microscale heterogeneities and experimental comparison. PTCOG 64, Jun 2026, Deauville, France. pp.101548, ⟨10.1016/j.ijpt.2026.101548⟩. ⟨hal-05801156⟩
  • Anne-Sophie Wozny, Mathilde Tissot, Sarah SebaĂŻ, Virginie Varoclier, CĂ©line MalĂ©sys, et al.. Carbon Ions selectively direct Oxidized Proteins toward Autophagy and Apoptosis via Mechanisms Distinct from Photondriven Proteasomal Degradation and UPR Activation. PTCOG64, PTCOG, Jun 2026, Deauville, France. ⟨hal-05698005⟩
  • H. Abdoul-Carime, E. Ogden, L. Biennier, S. Carles, F. Rabilloud. Low-energy electron-driven functionalization of benzene–water ices to phenol. Astronomy & Astrophysics - A&A, 2026, 710, pp.A94. ⟨10.1051/0004-6361/202659133⟩. ⟨hal-05656956⟩
  • Binjamyn Mairesse, Hamid Ladjal, Gersende Alphonse, CĂ©line Malesys, Etienne Testa, et al.. Segmentation et reconstruction 3D de lignĂ©es cellulaires par apprentissage profond Ă  partir des images confocales. Colloque Français d'Intelligence Artificielle en Imagerie BiomĂ©dicale (IABM 2026), Mar 2026, Lyon, France. ⟨hal-05479047⟩
  • Siamak Haghdoost, Juliette Thariat, Iluliana Toma-Dasu, Benjamin Frey, Claire Rodriguez-Lafrasse, et al.. Radiobiology Contributions and Perspectives in Hadron Therapy, with a focus on carbon ions: Report from the workshop Hadron therapy for life, Caen, March 2025. International Journal of Particle Therapy, 2026, 19, pp.101289. ⟨10.1016/j.ijpt.2025.101289⟩. ⟨hal-05386921v2⟩
  • Alexis Pereda, Thomas Berger, MichaĂ«l Beuve, Hermann Fuchs, Dietmar Georg, et al.. Calculating biological dose distributions in hadrontherapy using GATE: the BioDose actor. Phys.Med.Biol., 2026, 71 (15), pp.155027. ⟨10.1088/1361-6560/ae8358⟩. ⟨hal-05715274⟩
  • H Abdoul-Carime, J Kopyra. Slow-electron-triggered chemistry in interstellar methanol-water ices. Astronomy & Astrophysics - A&A, 2026, 712, pp.A216. ⟨10.1051/0004-6361/202660871⟩. ⟨hal-05741173⟩

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