Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
393 documents

  • Binjamyn Mairesse, Hamid Ladjal, Gersende Alphonse, Céline Malesys, Etienne Testa, et al.. Segmentation et reconstruction 3D de lignées cellulaires par apprentissage profond à partir des images confocales. Colloque Français d'Intelligence Artificielle en Imagerie Biomédicale (IABM 2026), Mar 2026, Lyon, France. ⟨hal-05479047⟩
  • Siamak Haghdoost, Juliette Thariat, Iluliana Toma-Dasu, Benjamin Frey, Claire Rodriguez-Lafrasse, et al.. Radiobiology Contributions and Perspectives in Hadron Therapy, with a focus on carbon ions: Report from the workshop Hadron therapy for life, Caen, March 2025. International Journal of Particle Therapy, 2026, 19, pp.101289. ⟨10.1016/j.ijpt.2025.101289⟩. ⟨hal-05386921⟩
  • N Frusciante, M Martinelli, L Lombriser, A Silvestri, M Archidiacono, et al.. Euclid preparation. Review of forecast constraints on dark energy and modified gravity. 2025. ⟨hal-05430473⟩
  • Floriane Poignant, Victor Levrague, Mathieu Roccia, Ngoc Hoang Tran, Sébastien Incerti, et al.. DNA decompaction enhances the formation of radiation-induced DNA double strand breaks and chromosome aberrations. Life Sciences in Space Research, 2025, ⟨10.1016/j.lssr.2025.10.006⟩. ⟨hal-05354503⟩
  • Binjamyn Mairesse, Hamid Ladjal, Michaël Beuve, Etienne Testa, Gersende Alphonse, et al.. Automatic Generation of 3D Cellular Geometries by Deep Learning for Monte Carlo Simulations. Industry Day LABEX PRIMES, 2025. ⟨hal-05166950⟩
  • Francoise Peyrin, Denis Dauvergne, Olivier Beuf (Dir.). Twelve Years of LabEx PRIMES (2012-2024). Zenodo, 2025, ⟨10.5281/zenodo.14794956⟩. ⟨hal-04928878v2⟩
  • Vincent Lequertier, Etienne Testa, Voichita Maxim. CoReSi: a GPU-based software for Compton camera reconstruction and simulation in collimator-free SPECT. Physics in Medicine and Biology, 2025, 70 (4), pp.19. ⟨10.1088/1361-6560/adaacc⟩. ⟨hal-04904932⟩
  • Janina Kopyra, Paulina Wierzbicka, Hassan Abdoul-Carime. Electron-Induced Fragmentation of 5-Iodouridine: Implications for Enhanced Radiotherapy. J.Phys.Chem.Lett., 2025, 16 (41), pp.10536-10541. ⟨10.1021/acs.jpclett.5c01615⟩. ⟨hal-05325526⟩
  • Hassan Abdoul-Carime, Janina Kopyra. Activation of Specific Reagents in Molecular Films by Sub-Ionization Electrons: Chlorobenzene/Water Films. International Journal of Molecular Sciences, 2025, 26 (17), pp.8751. ⟨10.3390/ijms26178751⟩. ⟨hal-05264445⟩
  • Victor Levrague, Mario Alcocer-Ávila, Sarah Leilla Otmani, Lydia Maigne, Etienne Testa, et al.. Impact of intracellular radionuclide distribution in a Monte Carlo biophysical 3D multi-cellular model for targeted alpha therapy. Medical Physics : The international journal of medical physics research and practice, 2025, 52 (7), pp.e17917. ⟨10.1002/mp.17917⟩. ⟨hal-05176560⟩

Powered by HAL logo