Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8782 documents

  • Hassan Abdoul-Carime, Louisa Castel, Franck Rabilloud. Insights into the C-Cl Bond Breaking in Epichlorohydrin Induced by Low Energy (<10 eV) Electrons. Molecules, 2024, 29 (24), pp.6051. ⟨10.3390/molecules29246051⟩. ⟨hal-04855194⟩
  • Salima Bourbia, Ayoub Karine, Aladine Chetouani, Mohammed El Hassouni, Maher Jridi. Blind point cloud quality assessment via 3D visual saliency and point-based neural network. The 13th International Conference on Image Processing Theory, Tools and Applications, Oct 2024, Rabat, Morocco. pp.01-06, ⟨10.1109/IPTA62886.2024.10755773⟩. ⟨hal-04693832⟩
  • Hassan Abdoul-Carime, Guillaume Thiam, Franck Rabilloud. Production of Nitrogen Dioxide, NO2 – , Anion from Dissociative Electron Attachment to Nitromethane below 1 eV and Its Temperature Dependence: Direct vs Dipole Bound Mediated Processes. Journal of Physical Chemistry Letters, 2024, 15 (41), pp.10329-10333. ⟨10.1021/acs.jpclett.4c02602⟩. ⟨hal-04753094⟩
  • H. Abdoul-Carime, Guillaume Thiam, Franck Rabilloud. Low Energy (<10 eV) Electron Collision with Benzonitrile‐CCl4 Admixture: A Combined Theoretical and Experimental Study. ChemPhysChem, 2024, 25 (16), pp.e202400287. ⟨10.1002/cphc.202400287⟩. ⟨hal-04753085⟩
  • Victor Levrague, R. Delorme, Mathieu Roccia, Ngoc Hoang Tran, Sebastien Incerti, et al.. Comparison of Geant4-DNA and RITRACKS/RITCARD: microdosimetry, nanodosimetry and DNA break predictions. 20th International Conference on the use of Computers in Radiation Therapy (ICCR), Jul 2024, Lyon, France, France. ⟨hal-04775893⟩
  • Safa Louati, Anne-Sophie Wozny, Céline Malesys, Elisabeth Daguenet, Riad Ladjohounlou, et al.. Differential Formation of Stress Granules in Radiosensitive and Radioresistant Head and Neck Squamous Cell Carcinoma Cells. International Journal of Radiation Oncology, Biology, Physics, 2024, 118 (2), pp.485-497. ⟨10.1016/j.ijrobp.2023.08.045⟩. ⟨hal-04518869⟩
  • Pierre Gazda, Bertrand Baujat, Jérôme Sarini, Anne Gomez-Brouchet, Pierre Philouze, et al.. Functional or radical surgical treatment of laryngeal chondrosarcoma, analysis of survival and prognostic factors: A REFCOR and NetSarc-ResOs multicenter study of 74 cases. EJSO - European Journal of Surgical Oncology, 2024, 50 (2), pp.107315. ⟨10.1016/j.ejso.2023.107315⟩. ⟨hal-04473760⟩
  • Mario Alcocer-Ávila, Victor Levrague, Rachel Delorme, Étienne Testa, Michaël Beuve. Biophysical modeling of low‐energy ion irradiations with NanOx. Medical Physics, 2024, 51 (12), pp.9358-9371. ⟨10.1002/mp.17407⟩. ⟨hal-04700855⟩
  • Jean Michel Létang, Oreste Allegrini, Etienne Testa. Prompt-gamma track-length estimator with time tagging from proton tracking. Physics in Medicine and Biology, 2024, 69 (11), pp.115052. ⟨10.1088/1361-6560/ad4a01⟩. ⟨hal-04572770⟩
  • Pierre Everaere, Denis Dauvergne, Marie-Laure Gallin-Martel, Joël Hérault, Ayoub Koudia, et al.. Prompt Gamma Energy Integration : a new method for online-range verification in proton therapy with pulsed-beams. Frontiers in Physics, 2024, 12, pp.1371015. ⟨10.3389/fphy.2024.1371015⟩. ⟨hal-04589792⟩

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