Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

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- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Francoise Peyrin, Denis Dauvergne, Olivier Beuf (Dir.). Twelve Years of LabEx PRIMES (2012-2024). Zenodo, 2025, ⟨10.5281/zenodo.14794956⟩. ⟨hal-04928878v2⟩
  • Vincent Lequertier, Etienne Testa, Voichita Maxim. CoReSi: a GPU-based software for Compton camera reconstruction and simulation in collimator-free SPECT. Physics in Medicine and Biology, 2025, 70 (4), pp.19. ⟨10.1088/1361-6560/adaacc⟩. ⟨hal-04904932⟩
  • Hamid Ladjal, Michael Beuve, Behzad Shariat. Patient-Specific Biomechanical Diaphragm-Ribs Respiratory Motion Model for Radiation Therapy. IEEE Transactions on Medical Robotics and Bionics, 2025, 7 (2), pp.802-813. ⟨10.1109/tmrb.2025.3560383⟩. ⟨hal-05110219⟩
  • Janina Kopyra, Aleksandr Bancer, Hassan Abdoul-Carime. Low energy electron induced fragmentation of hot asparagine and aspartic acid molecules. J.Chem.Phys., 2025, 162 (17), pp.174305. ⟨10.1063/5.0254082⟩. ⟨hal-05059790⟩
  • Hassan Abdoul-Carime, Janina Kopyra. Synthesis of Resorcinol and Chlorophenol from Irradiation of 1,3-Dichlorobenzene in a Water Ice Environment by Low-Energy Electrons. Int.J.Mol.Sci., 2025, 26 (2), pp.688. ⟨10.3390/ijms26020688⟩. ⟨hal-04906250⟩
  • Hassan Abdoul-Carime, Louisa Castel, Franck Rabilloud. Insights into the C-Cl Bond Breaking in Epichlorohydrin Induced by Low Energy (<10 eV) Electrons. Molecules, 2024, 29 (24), pp.6051. ⟨10.3390/molecules29246051⟩. ⟨hal-04855194⟩
  • Hassan Abdoul-Carime, Guillaume Thiam, Franck Rabilloud. Production of Nitrogen Dioxide, NO2 – , Anion from Dissociative Electron Attachment to Nitromethane below 1 eV and Its Temperature Dependence: Direct vs Dipole Bound Mediated Processes. Journal of Physical Chemistry Letters, 2024, 15 (41), pp.10329-10333. ⟨10.1021/acs.jpclett.4c02602⟩. ⟨hal-04753094⟩
  • H. Abdoul-Carime, Guillaume Thiam, Franck Rabilloud. Low Energy (<10 eV) Electron Collision with Benzonitrile‐CCl4 Admixture: A Combined Theoretical and Experimental Study. ChemPhysChem, 2024, 25 (16), pp.e202400287. ⟨10.1002/cphc.202400287⟩. ⟨hal-04753085⟩
  • Victor Levrague, R. Delorme, Mathieu Roccia, Ngoc Hoang Tran, Sebastien Incerti, et al.. Comparison of Geant4-DNA and RITRACKS/RITCARD: microdosimetry, nanodosimetry and DNA break predictions. 20th International Conference on the use of Computers in Radiation Therapy (ICCR), Jul 2024, Lyon, France, France. ⟨hal-04775893⟩
  • A. Pereda, Thomas Berger, Michaël Beuve, Jean Michel Létang, Etienne Testa, et al.. Implementation and validation of a biological dose actor in GATE 10. The 5th Geant4 International User Conference at the Physics-Medicine-Biology frontier, Mar 2024, Osaka, Japan. ⟨hal-05009136⟩

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