The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

Publications HAL


2021

Journal articles

M.-L. Gallin-Martel, S. Curtoni, S. Marcatili, L. Abbassi, A. Bes, et al.. X-ray beam induced current analysis of CVD diamond detectors in the perspective of a beam tagging hodoscope development for hadrontherapy on-line monitoring. Diamond and Related Materials, Elsevier, 2021, 112, pp.108236. ⟨10.1016/j.diamond.2020.108236⟩. ⟨hal-03150914⟩

Hamid Ladjal, Michael Beuve, Philippe Giraud, Shariat Behzad. Towards Non-invasive Lung Tumor Tracking Based on Patient-Specific Model of Respiratory System. IEEE Transactions on Biomedical Engineering, Institute of Electrical and Electronics Engineers, In press, ⟨10.1109/TBME.2021.3053321⟩. ⟨hal-03113681⟩

Oreste Allegrini, J. P. Cachemiche, C.P.C. Caplan, Bruno Carlus, Xiushan Chen, et al.. Characterization of a beam-tagging hodoscope for hadrontherapy monitoring. Journal of Instrumentation, IOP Publishing, In press. ⟨hal-03103624⟩

https://hal.archives-ouvertes.fr/hal-03103624/file/Allegrini.pdf

D. Sarrut, A. Etxebeste, N. Krah, Jm. Létang. Modeling complex particles phase space with GAN for Monte Carlo SPECT simulations: a proof of concept. Phys.Med.Biol., 2021, 66 (5), pp.055014. ⟨10.1088/1361-6560/abde9a⟩. ⟨hal-03150535⟩

2020

Journal articles

Rashmi Kumar, Hui Xiao Chao, Dennis Simpson, Wanjuan Feng, Min-Guk Cho, et al.. Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency. NAR Cancer, Oxford University Press, 2020, 2 (4), ⟨10.1093/narcan/zcaa038⟩. ⟨hal-03133102⟩

https://hal.archives-ouvertes.fr/hal-03133102/file/zcaa038.pdf

Nils Krah, Catherine Therese Quiñones, Jean-Michel Létang, Simon Rit. Scattering proton CT. Physics in Medicine and Biology, IOP Publishing, 2020, 65 (22), pp.225015. ⟨10.1088/1361-6560/abbd18⟩. ⟨hal-02959263⟩

https://hal.archives-ouvertes.fr/hal-02959263/file/scatteringpct_accepted.pdf

Riad Ladjohounlou, Safa Louati, Alexandra Lauret, Arnaud Gauthier, Dominique Ardail, et al.. Ceramide-Enriched Membrane Domains Contribute to Targeted and Nontargeted Effects of Radiation through Modulation of PI3K/AKT Signaling in HNSCC Cells. International Journal of Molecular Sciences, MDPI, 2020, 21 (19), pp.7200. ⟨10.3390/ijms21197200⟩. ⟨hal-03001763⟩

Floriane Poignant, Hela Charfi, Chen-Hui Chan, Elise Dumont, David Loffreda, et al.. Monte Carlo simulation of free radical production under keV photon irradiation of gold nanoparticle aqueous solution. Part I: Global primary chemical boost. Radiation Physics and Chemistry, Elsevier, 2020, 172, pp.108790. ⟨10.1016/j.radphyschem.2020.108790⟩. ⟨hal-02498384⟩

https://hal.archives-ouvertes.fr/hal-02498384/file/RPC-172-2020-108790-preprint%20%281%29.pdf

Hamid Ladjal, Matthieu Giroux, Michael Beuve, Philippe Giraud, Behzad Shariat. Patient-specific physiological model of the respiratory system based on inverse finite element analysis: a comparative study. Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis, 2020, Computer Methods in Biomechanics and Biomedical Engineering, 22 (sup1), pp.S45-S47. ⟨10.1080/10255842.2020.1713473⟩. ⟨hal-02466130⟩

Feriel Khellaf, Nils Krah, Jean Michel Létang, Simon Rit. 2D directional ramp filter. Physics in Medicine and Biology, IOP Publishing, 2020, 65 (8), pp.08NT01. ⟨10.1088/1361-6560/ab7875⟩. ⟨hal-02486620⟩

https://hal.archives-ouvertes.fr/hal-02486620/file/PMB_DR.pdf

S. Simonet, C. Rodriguez-Lafrasse, D. Béal, S. Gerbaud, C. Malesys, et al.. Gadolinium-Based Nanoparticles Can Overcome the Radioresistance of Head and Neck Squamous Cell Carcinoma Through the Induction of Autophagy. Journal of Biomedical Nanotechnology, American Scientific Publishers, 2020, 16 (1), pp.111-124. ⟨10.1166/jbn.2020.2871⟩. ⟨hal-02476855⟩

W. B. Li, A. Belchior, M. Beuve, Y. Z. Chen, S. Di Maria, et al.. Intercomparison of dose enhancement ratio and secondary electron spectra for gold nanoparticles irradiated by X-rays calculated using multiple Monte Carlo simulation codes. Physica Medica, Elsevier, 2020, 69, pp.147-163. ⟨10.1016/j.ejmp.2019.12.011⟩. ⟨hal-02452613⟩

https://hal.archives-ouvertes.fr/hal-02452613/file/PIIS1120179719305320.pdf

Chen-Hui Chan, Floriane Poignant, Michael Beuve, Elise Dumont, David Loffreda. Effect of the Ligand Binding Strength on the Morphology of Functionalized Gold Nanoparticles. Journal of Physical Chemistry Letters, American Chemical Society, 2020, pp.2717-2723. ⟨10.1021/acs.jpclett.0c00300⟩. ⟨hal-02519412⟩

https://hal.archives-ouvertes.fr/hal-02519412/file/jz-2020-003008.R1_Proof_hi.pdf

Floriane Poignant, Caterina Monini, Étienne Testa, Michaël Beuve. Influence of gold nanoparticles embedded in water on nanodosimetry for keV photon irradiation. Medical Physics, American Association of Physicists in Medicine, In press, ⟨10.1002/mp.14576⟩. ⟨hal-03001810⟩

Feriel Khellaf, Nils Krah, Jean-Michel Létang, Charles-Antoine Collins-Fekete, Simon Rit. A comparison of direct reconstruction algorithms in proton computed tomography. Physics in Medicine and Biology, IOP Publishing, 2020, 65 (10), pp.105010. ⟨10.1088/1361-6560/ab7d53⟩. ⟨hal-02502179⟩

https://hal.archives-ouvertes.fr/hal-02502179/file/PMB_comparison.pdf

M. Fontana, J.-L. Ley, D. Dauvergne, Nicolas Freud, J. Krimmer, et al.. Monitoring ion beam therapy with a Compton Camera: simulation studies of the clinical feasibility. IEEE Trans.Rad.Plasma Med.Sci., 2020, 4 (2), pp.218-232. ⟨10.1109/TRPMS.2019.2933985⟩. ⟨hal-02301075⟩

Denis Dauvergne, Oreste Allegrini, Cairo Caplan, Xiushan Chen, Sébastien Curtoni, et al.. On the role of single particle irradiation and fast timing for efficient online-control in particle therapy. Frontiers in Physics, Frontiers, 2020, 8, pp.567215. ⟨10.3389/fphy.2020.567215⟩. ⟨hal-02939215⟩

https://hal.archives-ouvertes.fr/hal-02939215/file/Dauvergne_fphy-08-567215.pdf

Fatmir Asllanaj, Ahmad Addoum. Simultaneous reconstruction of absorption, scattering and anisotropy factor distributions in quantitative photoacoustic tomography. Biomed.Phys.Eng.Express, 2020, 6 (4), pp.045010. ⟨10.1088/2057-1976/ab90a0⟩. ⟨hal-02870842⟩

https://hal.archives-ouvertes.fr/hal-02870842/file/article%20%281%29.pdf

S. Marcatili, J. Collot, S. Curtoni, Denis Dauvergne, J.-Y. Hostachy, et al.. Ultra-fast prompt gamma detection in single proton counting regime for range monitoring in particle therapy. Phys.Med.Biol., 2020, 65 (24), pp.245033. ⟨10.1088/1361-6560/ab7a6c⟩. ⟨hal-02467231⟩ https://arxiv.org/pdf/2001.01470

Paulina Stasica, Jakub Baran, Carlos Granja, Nils Krah, Grzegorz Korcyl, et al.. A Simple Approach for Experimental Characterization and Validation of Proton Pencil Beam Profiles. Front.in Phys., 2020, 8, pp.346. ⟨10.3389/fphy.2020.00346⟩. ⟨hal-02999622⟩