Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for Physics Beyond the Standard Model in Events with High-Momentum Higgs Bosons and Missing Transverse Momentum in Proton-Proton Collisions at 13 TeV. Phys.Rev.Lett., 2018, 120 (24), pp.241801. ⟨10.1103/PhysRevLett.120.241801⟩. ⟨hal-01823318⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Studies of {\mathrm {B}} ^{*}_{\mathrm {s}2}(5840)^0 and {\mathrm {B}} _{{\mathrm {s}}1}(5830)^0 mesons including the observation of the {\mathrm {B}} ^{*}_{\mathrm {s}2}(5840)^0 \rightarrow {\mathrm {B}} ^0 \mathrm {K} ^0_{\mathrm {S}} decay in proton-proton collisions at \sqrt{s}=8\,\text {TeV}. Eur.Phys.J.C, 2018, 78 (11), pp.939. ⟨10.1140/epjc/s10052-018-6390-z⟩. ⟨hal-01885926⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Study of jet quenching with isolated-photon+jet correlations in PbPb and pp collisions at \sqrt{s_{_{\mathrm{NN}}}} = 5.02 TeV. Physics Letters B, 2018, 785, pp.14-39. ⟨10.1016/j.physletb.2018.07.061⟩. ⟨hal-01867382⟩
  • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of quarkonium production cross sections in pp collisions at \sqrt{s}= 13 TeV. Physics Letters B, 2018, 780, pp.251-272. ⟨10.1016/j.physletb.2018.02.033⟩. ⟨hal-01758282⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of angular parameters from the decay \mathrm{B}^0 \to \mathrm{K}^{*0} \mu^+ \mu^- in proton-proton collisions at \sqrt{s} = 8 TeV. Physics Letters B, 2018, 781, pp.517-541. ⟨10.1016/j.physletb.2018.04.030⟩. ⟨hal-01797563⟩
  • C. Delafosse, D. Verney, P. Marević, A. Gottardo, C. Michelagnoli, et al.. Pseudospin Symmetry and Microscopic Origin of Shape Coexistence in the ^{78}Ni Region: A Hint from Lifetime Measurements. Physical Review Letters, 2018, 121 (19), pp.192502. ⟨10.1103/PhysRevLett.121.192502⟩. ⟨hal-01922075⟩
  • A. M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Elliptic flow of charm and strange hadrons in high-multiplicity pPb collisions at \sqrt{s_{_\mathrm{NN}}} = 8.16 TeV. Physical Review Letters, 2018, 121 (8), pp.082301. ⟨10.1103/PhysRevLett.121.082301⟩. ⟨hal-01797077⟩
  • Maria Boltoeva, Clotilde Gaillard, Sylvia Georg, Vasilii K. Karandashev, Alexander N. Turanov. Speciation of uranium(VI) extracted from acidic nitrate media by TODGA into molecular and ionic solvents. Separation and Purification Technology, 2018, 203, pp.11-19. ⟨10.1016/j.seppur.2018.04.003⟩. ⟨hal-01867856⟩
  • S. Acharya, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, Gianluca Aglieri Rinella, et al.. Search for collectivity with azimuthal J/\psi-hadron correlations in high multiplicity p-Pb collisions at \sqrt{s_{\rm NN}} = 5.02 and 8.16 TeV. Physics Letters B, 2018, 780, pp.7-20. ⟨10.1016/j.physletb.2018.02.039⟩. ⟨hal-01757943⟩
  • C. Babusiaux, F. van Leeuwen, M. Barstow, A. M., C. Jordi, et al.. VizieR Online Data Catalog: 46 open clusters GaiaDR2 HR diagrams (Gaia Collaboration, 2018). 2018. ⟨hal-01867430⟩

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