Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • N. Lalović, D. Rudolph, Zs Podolyák, L.G. Sarmiento, E.C. Simpson, et al.. Study of isomeric states in ^{198,200,202,206}Pb and ^{206}Hg populated in fragmentation reactions. Journal of Physics G: Nuclear and Particle Physics, 2018, 45 (3), pp.035105. ⟨10.1088/1361-6471/aaa9df⟩. ⟨hal-01714621⟩
    • K. Hadyńska-Klȩk, P.J. Napiorkowski, M. Zielińska, J. Srebrny, A. Maj, et al.. Quadrupole collectivity in ^{42}\mathrm{Ca} from low-energy Coulomb excitation with AGATA. Physical Review C, 2018, 97 (2), pp.024326. ⟨10.1103/PhysRevC.97.024326⟩. ⟨hal-01730128⟩
    • S. Acharya, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, Gianluca Aglieri Rinella, et al.. First measurement of \Xi_{\rm c}^0 production in pp collisions at \mathbf{\sqrt{s}} = 7 TeV. Phys.Lett.B, 2018, 781, pp.8-19. ⟨10.1016/j.physletb.2018.03.061⟩. ⟨hal-01768086⟩
    • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of normalized differential \mathrm{t}\overline{\mathrm{t}} cross sections in the dilepton channel from pp collisions at \sqrt{s}=13 TeV. JHEP, 2018, 04, pp.060. ⟨10.1007/JHEP04(2018)060⟩. ⟨hal-01797353⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of the groomed jet mass in PbPb and pp collisions at \sqrt{s_{\mathrm{NN}}}=5.02 TeV. JHEP, 2018, 10, pp.161. ⟨10.1007/JHEP10(2018)161⟩. ⟨hal-01801906⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Constraints on the chiral magnetic effect using charge-dependent azimuthal correlations in p\mathrm{Pb} and PbPb collisions at the CERN Large Hadron Collider. Phys.Rev.C, 2018, 97 (4), pp.044912. ⟨10.1103/PhysRevC.97.044912⟩. ⟨hal-01782023⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for narrow and broad dijet resonances in proton-proton collisions at \sqrt{s}=13 TeV and constraints on dark matter mediators and other new particles. JHEP, 2018, 08, pp.130. ⟨10.1007/JHEP08(2018)130⟩. ⟨hal-01817964⟩
    • A. M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Observation of the \chi_\mathrm{b1}(3P) and \chi_\mathrm{b2}(3P) and measurement of their masses. Phys.Rev.Lett., 2018, 121, pp.092002. ⟨10.1103/PhysRevLett.121.092002⟩. ⟨hal-01815242⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for third-generation scalar leptoquarks decaying to a top quark and a \tau lepton at \sqrt{s}= 13 TeV. Eur.Phys.J.C, 2018, 78, pp.707. ⟨10.1140/epjc/s10052-018-6143-z⟩. ⟨hal-01758566⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Observation of proton-tagged, central (semi)exclusive production of high-mass lepton pairs in pp collisions at 13 TeV with the CMS-TOTEM precision proton spectrometer. JHEP, 2018, 07, pp.153. ⟨10.1007/JHEP07(2018)153⟩. ⟨hal-01758051⟩

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