Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • G. Ramirez-Sanchez, A. Fagot, M. Gul, C. Roskas, M. Tytgat, et al.. Search for Heavy Stable Charged Particles in the CMS Experiment using the RPC Phase II upgraded detectors. 14th Workshop on Resistive Plate Chambers and Related Detectors, Feb 2018, Puerto Vallarta, Mexico. pp.C11011, ⟨10.1088/1748-0221/14/11/C11011⟩. ⟨hal-02403553⟩
    • R. Reyes-Almanza, A. Dimitrov, A. Fagot, M. Gul, C. Roskas, et al.. High voltage calibration method for the CMS RPC detector. 14th Workshop on Resistive Plate Chambers and Related Detectors, Feb 2018, Puerto Vallarta, Mexico. pp.C09046, ⟨10.1088/1748-0221/14/09/C09046⟩. ⟨hal-02338396⟩
    • A. Fagot, M. Gul, C. Roskas, M. Tytgat, N. Zaganidis, et al.. Fast timing measurement for CMS RPC Phase-II upgrade. 14th Workshop on Resistive Plate Chambers and Related Detectors, Feb 2018, Puerto Vallarta, Mexico. pp.C09001, ⟨10.1088/1748-0221/13/09/C09001⟩. ⟨hal-01897175⟩
    • R. Caravita, S. Mariazzi, S. Aghion, C. Amsler, M. Antonello, et al.. Positronium Rydberg excitation diagnostic in a 1T cryogenic environment. 18th International Conference on Positron Annihilation, Feb 2018, Orlando, United States. pp.030002, ⟨10.1063/1.5135825⟩. ⟨hal-03830379⟩
    • B. Mandelli, R. Guida, M. Gagliardi, M. Marchisone. Gas mixture quality monitoring for the RPC detectors at the LHC experiments. 14th Workshop on Resistive Plate Chambers and Related Detectors, Feb 2018, Puerto Vallarta, Mexico. pp.C09006, ⟨10.1088/1748-0221/14/09/C09006⟩. ⟨hal-02317326⟩
    • M.I. Pedraza-Morales, D. Han, B. Boghrati, A. Fagot, M. Gul, et al.. RPC upgrade project for CMS Phase II. 14th Workshop on Resistive Plate Chambers and Related Detectors, Feb 2018, Puerto Vallarta, Mexico. pp.C05072, ⟨10.1088/1748-0221/15/05/C05072⟩. ⟨hal-03164491⟩
    • A. Gelmi, A. Fagot, M. Gul, C. Roskas, M. Tytgat, et al.. Longevity studies on the CMS-RPC system. 14th Workshop on Resistive Plate Chambers and Related Detectors, Feb 2018, Puerto Vallarta, Mexico. pp.C05012, ⟨10.1088/1748-0221/14/05/C05012⟩. ⟨hal-02148269⟩
    • E. Voevodina, A. Fagot, M. Gul, C. Roskas, M. Tytgat, et al.. RE3/1 \& RE4/1 RPC chambers integration in the inner region of the forward muon spectrometer in the CMS experiment. 14th Workshop on Resistive Plate Chambers and Related Detectors, Feb 2018, Puerto Vallarta, Mexico. pp.C10027, ⟨10.1088/1748-0221/14/10/C10027⟩. ⟨hal-02363426⟩
    • M.A. Shah, R. Hadjiska, A. Fagot, M. Gul, C. Roskas, et al.. The CMS RPC Detector Performance and Stability during LHC RUN-2. 14th Workshop on Resistive Plate Chambers and Related Detectors, Feb 2018, Puerto Vallarta, Mexico. pp.C11012, ⟨10.1088/1748-0221/14/11/C11012⟩. ⟨hal-01876355⟩
    • D. Autiero. Current IN2P3 activities in DUNE/protoDUNE. Journée DUNE France, Feb 2018, Paris, France. ⟨in2p3-02107069⟩

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