Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • A. Arbey. Big-Bang Nucleosynthesis, early universe and relic particles. 53rd Rencontres de Moriond on Cosmology, Mar 2018, La Thuile, Italy. pp.189-192. ⟨hal-02946221⟩
    • Solen Le Corre. Higgs boson phenomenology beyond the Standard Model. Nuclear Theory [nucl-th]. Université de Lyon, 2018. English. ⟨NNT : 2018LYSE1028⟩. ⟨tel-01983201⟩
    • Nicola Zurlo, Stefano Aghion, Claude Amsler, Massimiliano Antonello, Alexandre Belov, et al.. Monte-Carlo simulation of positronium laser excitation and anti-hydrogen formation via charge exchange. 13th International Conference on Low Energy Antiproton Physics, Mar 2018, Paris, France. pp.18, ⟨10.1007/s10751-019-1553-3⟩. ⟨hal-02073531⟩
    • S. Jamal, V. Le Brun, O. Le Fevre, D. Vibert, Anne Schmitt, et al.. Automated reliability assessment for spectroscopic redshift measurements. Astronomy & Astrophysics - A&A, 2018, 611, ⟨10.1051/0004-6361/201731305⟩. ⟨hal-01796785⟩
    • Hugues Lattaud. Jet Energy calibration and resolution at the CMS experiment with 13 TeV collisions. Poster @LHCC, Feb 2018, CERN, Switzerland. ⟨hal-02023525⟩
    • F. Mahmoudi, T. Hurth, S. Neshatpour. New physics effects in B-decays. 32nd Rencontres de Physique de La Vallée d'Aoste, Feb 2018, La Thuile, Italy. pp.143, ⟨10.1393/ncc/i2018-18143-3⟩. ⟨hal-03563972⟩
    • Fabienne Lagarde, A. Fagot, M. Gul, C. Roskas, M. Tytgat, et al.. High Rate RPC detector for LHC. 14th Workshop on Resistive Plate Chambers and Related Detectors, Feb 2018, Puerto Vallarta, Mexico. pp.C10037, ⟨10.1088/1748-0221/14/10/C10037⟩. ⟨hal-01862019⟩
    • C. Uribe Estrada, S.Carpinteyro Bernardino, A.Castaneda Hernandez, A. Fagot, M. Gul, et al.. RPC radiation background simulations for the high luminosity phase in the CMS experiment. 14th Workshop on Resistive Plate Chambers and Related Detectors, Feb 2018, Puerto Vallarta, Mexico. pp.C09045, ⟨10.1088/1748-0221/14/09/C09045⟩. ⟨hal-02338397⟩
    • J. Goh, A. Fagot, M. Gul, C. Roskas, M. Tytgat, et al.. CMS RPC efficiency measurement using the tag-and-probe method. 14th Workshop on Resistive Plate Chambers and Related Detectors, Feb 2018, Puerto Vallarta, Mexico. pp.C10020, ⟨10.1088/1748-0221/14/10/C10020⟩. ⟨hal-02393843⟩
    • G. Ramirez-Sanchez, A. Fagot, M. Gul, C. Roskas, M. Tytgat, et al.. Search for Heavy Stable Charged Particles in the CMS Experiment using the RPC Phase II upgraded detectors. 14th Workshop on Resistive Plate Chambers and Related Detectors, Feb 2018, Puerto Vallarta, Mexico. pp.C11011, ⟨10.1088/1748-0221/14/11/C11011⟩. ⟨hal-02403553⟩

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