Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • D. Contardo. CMS Upgrade plans. Sixth Common ATLAS CMS Electronics Workshop for LHC Upgrades (ACES) Workshop, Apr 2018, Genève, Switzerland. ⟨hal-02063954⟩
    • Anne-Sophie Wozny, Guillaume Vares, Tetsuo Nakajima, Akira Fujimori, Michael Beuve, et al.. Role of HIF-1α in the migration/invasion processes in response to photon and C-ion irradiations. ESTRO 37 - Innovation for Value and Access, Apr 2018, Barcelona, Spain. ⟨hal-02064756⟩
    • Hugues Lattaud. Study of photon + jet events to constrain the jet energy scale in CMS. Alps 2018, Apr 2018, Obergurgl, Austria. ⟨hal-02023557⟩
    • T.D. Märk, F. Berthias, T. Salbaing, L. Feketeová, H. Abdoul-Carime, et al.. Non-statistical evaporation from excited water cluster ions. 3rd International Workshop on Dissociative Electron Attachment, Apr 2018, Prague, Czech Republic. ⟨in2p3-02098140⟩
    • R. Meissner, L. Feketeová, Paulo LimĂŁo-Vieira, S. Denifl. Dissociative electron attachment to nimorazole. 3rd International Workshop on Dissociative Electron Attachment, Apr 2018, Prague, Czech Republic. ⟨in2p3-02098133⟩
    • Marina Rosas-Carbajal, Jacques Marteau, Matias Tramontini, Fabio Zyserman, Jean de Bremond d'Ars, et al.. Muon tomography of the La Soufrière de Guadeloupe hydrothermal system: 3-D structure and dynamics . European Geosciences Union General Assembly 2018, Apr 2018, Vienne, Austria. Geophysical Research Abstracts, 20, pp.EGU2018-18548, 2018. ⟨insu-01768604⟩
    • Giovanna Muggiolu, Sarah Libert, Alexandra Lauret, Philippe CĂ©ruse, Christian Adrien Righini, et al.. Stratification of Head and Neck Cancers: DNA Repair Enzyme Signature to Identify Resistance and Toxicity Biomarkers. Forum de la recherche en CancĂ©rologie 2018, Apr 2018, Villeurbanne, France. ⟨hal-01990547⟩
    • O. StĂ©zowski. AGATA-GRETINA Processing and Neural Networks. Second AGATA-GRETINA tracking arrays collaboration meeting, Apr 2018, Orsay, France. ⟨in2p3-02101706⟩
    • M. Gouzevitch. HH->bbbb boosted. 3rd CMS HH Workshop, Apr 2018, Paris, France. ⟨hal-02076991⟩
    • Floriane Poignant, BenoĂ®t Gervais, Andrei Ipatov, Hela Charfi, Etienne Testa, et al.. ModĂ©lisation physique, chimique et biologique pour la radiothĂ©rapie amĂ©liorĂ©e par les nanoparticules Ă  fort-Z : vers une meilleure comprĂ©hension de l’effet radiosensibilisant. Forum de la recherche en CancĂ©rologie 2018, Apr 2018, Villeurbanne, France. ⟨hal-01989615⟩

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