Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- D. Kikoła, S.J. Brodsky, G. Cavoto, C. da Silva, F. Donato, et al.. A fixed-target programme at the LHC for heavy-ion, hadron, spin and astroparticle physics: AFTER@LHC. 27th International Conference on Ultrarelativistic Nucleus-Nucleus Collisions, May 2018, Venice, Italy. pp.971-974, ⟨10.1016/j.nuclphysa.2018.09.063⟩. ⟨hal-02058426⟩
- J. Bryslawskyj, E.T. Atomssa, Z.C. del Valle, O. Drapier, F. Fleuret, et al.. PHENIX study of the initial state with forward hadron measurements in 200 GeV p(d)+A and 3He+Au collisions. 27th International Conference on Ultrarelativistic Nucleus-Nucleus Collisions (Quark Matter), May 2018, Venise, Italy. pp.275-278, ⟨10.1016/j.nuclphysa.2018.09.070⟩. ⟨in2p3-02045424⟩
- Alan Mcconnachie, Carine Babusiaux, Michael Balogh, Simon Driver, Pat Côté, et al.. The Detailed Science Case for the Maunakea Spectroscopic Explorer: the Composition and Dynamics of the Faint Universe. 2018. ⟨hal-01596124⟩
- Farvah Mahmoudi, Alexandre Arbey, Tobias Hurth, Siavash Neshatpour. BSM fits for rare B decays. 17th International Conference on B-Physics at Frontier Machines, May 2018, La Biodola, Italy. pp.040, ⟨10.22323/1.326.0040⟩. ⟨hal-01937557⟩
- D. Autiero. Charge Readout and dual phase. AIDA−2020 3th Annual Meeting, Apr 2018, Bologna, Italy. ⟨in2p3-02107281⟩
- D. Autiero. Overview WP8 scientific goals. AIDA−2020 3th Annual Meeting, Apr 2018, Bologna, Italy. ⟨in2p3-02107278⟩
- D. Contardo. CMS Upgrade plans. Sixth Common ATLAS CMS Electronics Workshop for LHC Upgrades (ACES) Workshop, Apr 2018, Genève, Switzerland. ⟨hal-02063954⟩
- Anne-Sophie Wozny, Guillaume Vares, Tetsuo Nakajima, Akira Fujimori, Michael Beuve, et al.. Role of HIF-1α in the migration/invasion processes in response to photon and C-ion irradiations. ESTRO 37 - Innovation for Value and Access, Apr 2018, Barcelona, Spain. ⟨hal-02064756⟩
- Hugues Lattaud. Study of photon + jet events to constrain the jet energy scale in CMS. Alps 2018, Apr 2018, Obergurgl, Austria. ⟨hal-02023557⟩
- T.D. Märk, F. Berthias, T. Salbaing, L. Feketeová, H. Abdoul-Carime, et al.. Non-statistical evaporation from excited water cluster ions. 3rd International Workshop on Dissociative Electron Attachment, Apr 2018, Prague, Czech Republic. ⟨in2p3-02098140⟩
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