Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • Rémi Barbier, Sylvain Ferriol, Bogna Kubik, Gérard Smadja, Aurélia Secroun, et al.. Detector chain calibration strategy for the Euclid Flight IR H2RGs. SPIE Astronomical Telescopes + Instrumentation 2018, Jun 2018, Austin, United States. pp.107090S, ⟨10.1117/12.2311966⟩. ⟨hal-01959781⟩
    • F. Mahmoudi. Supersymmetry, direct and indirect constraints. 7th Workshop on Theory, Phenomenology and Experiments in Flavour Physics, Jun 2018, Anacapri, Italy. pp.37-42, ⟨10.1016/j.nuclphysbps.2019.03.008⟩. ⟨hal-01975274⟩
    • Abdulhamid Chaikh, Valentin Calugaru, Pierre-Yves Bondiau, Juliette Thariat, Jacques Balosso. Impact of the NTCP modeling on medical decision to select eligible patient for proton therapy: the usefulness of EUD as an indicator to rank modern photon vs proton treatment plans. International Journal of Radiation Biology, 2018, pp.1 - 26. ⟨10.1080/09553002.2018.1486516⟩. ⟨in2p3-01834894⟩
    • Andrey Popov. Searches for additional Higgs bosons. 6th Large Hadron Collider Physics Conference (LHCP 2018), Jun 2018, Bologna, Italy. ⟨hal-02019026⟩
    • C. Aidala, Y. Akiba, M. Alfred, V. Andrieux, N. Apadula, et al.. Correlations of \mu\mu, e\mu, and ee pairs in p+p collisions at \sqrt{s}=200 GeV and implications for c\bar{c} and b\bar{b} production mechanisms. 2018. ⟨hal-01801851⟩
    • Alberto Annovi, Giovanni Calderini, Stefano Capra, Bruno Checcucci, Francesco Crescioli, et al.. Characterization of an Associative Memory Chip in 28 nm CMOS Technology. IEEE International Symposium on Circuits and Systems, May 2018, Florence, Italy. pp.5, ⟨10.1109/ISCAS.2018.8351801⟩. ⟨hal-01959786⟩
    • Nicolas Chanon. Matrix Element Method at ATLAS and CMS. Top LHC France 2018, May 2018, Paris, France. ⟨hal-02052629⟩
    • Andrey Popov. Search for ttbar resonances. Top LHC France 2018, May 2018, Paris, France. ⟨hal-02019007⟩
    • S. Beauceron. Single T'->tH(bb) all-hadronic resolved. B2G Spring Workshop 2018, May 2018, Hambourg, Germany. ⟨hal-02063442⟩
    • Nicolas Chanon. IPNL-PKU CMS Collaboration on ttH. Workshop France China Particle Physics Laboratory (FCPPL) 2018, May 2018, Marseille, France. ⟨hal-02052660⟩

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