Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Wafa Bouleftour, Benoite Mery, Elise Rowinski, Charlene Rivier, Elisabeth Daguenet, et al.. Cardio-Oncology Preclinical Models: A Comprehensive Review. Anticancer Research, 2021, 41 (11), pp.5355-5364. ⟨10.21873/anticanres.15348⟩. ⟨hal-03463909⟩
    • Pablo Lemos, Niall Jeffrey, Lorne Whiteway, Ofer Lahav, Noam I. Libeskind, et al.. Sum of the masses of the Milky Way and M31: A likelihood-free inference approach. Physical Review D, 2021, 103 (2), pp.023009. ⟨10.1103/PhysRevD.103.023009⟩. ⟨hal-02999468⟩
    • Oreste Allegrini, J. P. Cachemiche, C.P.C. Caplan, Bruno Carlus, Xiushan Chen, et al.. Characterization of a beam-tagging hodoscope for hadrontherapy monitoring. Journal of Instrumentation, 2021, 16, pp.P02028. ⟨10.1088/1748-0221/16/02/P02028⟩. ⟨hal-03103624⟩
    • C. Hadjidakis, D. KikoĹ‚a, J.P. Lansberg, L. Massacrier, M.G. Echevarria, et al.. A fixed-target programme at the LHC: Physics case and projected performances for heavy-ion, hadron, spin and astroparticle studies. Physics Reports, 2021, 911, pp.1-83. ⟨10.1016/j.physrep.2021.01.002⟩. ⟨hal-01846818⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, et al.. Performance of the CMS muon trigger system in proton-proton collisions at \sqrt{s} = 13 TeV. JINST, 2021, 16, pp.P07001. ⟨10.1088/1748-0221/16/07/P07001⟩. ⟨hal-03157137⟩
    • Armen Tumasyan, Wolfgang Adam, Janik Walter Andrejkovic, Thomas Bergauer, Suman Chatterjee, et al.. Search for Long-Lived Particles Decaying in the CMS End Cap Muon Detectors in Proton-Proton Collisions at \sqrt s =13  TeV. Phys.Rev.Lett., 2021, 127 (26), pp.261804. ⟨10.1103/PhysRevLett.127.261804⟩. ⟨hal-03312916⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, et al.. Search for dark matter produced in association with a leptonically decaying Z boson in proton-proton collisions at \sqrt{s} = 13 TeV. Eur.Phys.J.C, 2021, 81 (1), pp.13. ⟨10.1140/epjc/s10052-020-08739-5⟩. ⟨hal-02934005⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurement of b jet shapes in proton-proton collisions at \sqrt{s} = 5.02 TeV. JHEP, 2021, 05, pp.054. ⟨10.1007/JHEP05(2021)054⟩. ⟨hal-02870840⟩
    • David Sarrut, A. Etxebeste, Nils Krah, Jean Michel LĂ©tang. Modeling complex particles phase space with GAN for Monte Carlo SPECT simulations: a proof of concept. Physics in Medicine and Biology, 2021, 66 (5), pp.055014. ⟨10.1088/1361-6560/abde9a⟩. ⟨hal-03150535⟩
    • Janina Kopyra, Franck Rabilloud, Paulina Wierzbicka, Hassan Abdoul-Carime. Energy-Selective Decomposition of Organometallic Compounds by Slow Electrons: The Case of Chloro(dimethyl sulfide)gold(I). Journal of Physical Chemistry A, 2021, 125 (4), pp.966-972. ⟨10.1021/acs.jpca.0c09988⟩. ⟨hal-03148189⟩

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