Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8788 documents

  • C. Hadjidakis, D. KikoĹ‚a, J.P. Lansberg, L. Massacrier, M.G. Echevarria, et al.. A fixed-target programme at the LHC: Physics case and projected performances for heavy-ion, hadron, spin and astroparticle studies. Physics Reports, 2021, 911, pp.1-83. ⟨10.1016/j.physrep.2021.01.002⟩. ⟨hal-01846818⟩
  • Oreste Allegrini, J. P. Cachemiche, C.P.C. Caplan, Bruno Carlus, Xiushan Chen, et al.. Characterization of a beam-tagging hodoscope for hadrontherapy monitoring. Journal of Instrumentation, 2021, 16, pp.P02028. ⟨10.1088/1748-0221/16/02/P02028⟩. ⟨hal-03103624⟩
  • Pablo Lemos, Niall Jeffrey, Lorne Whiteway, Ofer Lahav, Noam I. Libeskind, et al.. Sum of the masses of the Milky Way and M31: A likelihood-free inference approach. Physical Review D, 2021, 103 (2), pp.023009. ⟨10.1103/PhysRevD.103.023009⟩. ⟨hal-02999468⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurement of b jet shapes in proton-proton collisions at \sqrt{s} = 5.02 TeV. JHEP, 2021, 05, pp.054. ⟨10.1007/JHEP05(2021)054⟩. ⟨hal-02870840⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, et al.. Performance of the CMS muon trigger system in proton-proton collisions at \sqrt{s} = 13 TeV. JINST, 2021, 16, pp.P07001. ⟨10.1088/1748-0221/16/07/P07001⟩. ⟨hal-03157137⟩
  • The Cms Collaboration, Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, et al.. Search for new physics in top quark production with additional leptons in proton-proton collisions at \sqrt{s} = 13 TeV using effective field theory. JHEP, 2021, 03, pp.095. ⟨10.1007/JHEP03(2021)095⟩. ⟨hal-03098879⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Correlations of azimuthal anisotropy Fourier harmonics with subevent cumulants in pPb collisions at \sqrt{s_{NN}}=8.16TeV. Phys.Rev.C, 2021, 103 (1), pp.014902. ⟨10.1103/PhysRevC.103.014902⟩. ⟨hal-02154224⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, et al.. Observation of Forward Neutron Multiplicity Dependence of Dimuon Acoplanarity in Ultraperipheral Pb-Pb Collisions at \sqrt{s_{NN}}=5.02  TeV. Physical Review Letters, 2021, 127 (12), pp.122001. ⟨10.1103/PhysRevLett.127.122001⟩. ⟨hal-03034799⟩
  • J.-B. Salomon, R Ibata, C. ReylĂ©, Benoit Famaey, N Libeskind, et al.. The proper motion of Andromeda from Gaia EDR3: confirming a nearly radial orbit. Monthly Notices of the Royal Astronomical Society, 2021, 507 (2), pp.2592-2601. ⟨10.1093/mnras/stab2253⟩. ⟨hal-03825962⟩
  • Hamid Ladjal, Michael Beuve, Philippe Giraud, Shariat Behzad. Towards Non-invasive Lung Tumor Tracking Based on Patient-Specific Model of Respiratory System. IEEE Transactions on Biomedical Engineering, 2021, 68 (9), pp.2730-2740. ⟨10.1109/TBME.2021.3053321⟩. ⟨hal-03113681⟩

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