Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • Z. Citron, A. Dainese, J.F. Grosse-Oetringhaus, J.M. Jowett, Y.-J. Lee, et al.. Future physics opportunities for high-density QCD at the LHC with heavy-ion and proton beams. HL/HE-LHC Workshop, Jun 2018, Geneva, Switzerland. ⟨hal-01974840⟩
    • A. Valcarce, J.-M. Richard, J. Vijande. Basics of doubly heavy tetraquarks. 13th International Conference on Beauty, Charm and Hyperons, Jun 2018, Peniche, Portugal. pp.012038, ⟨10.1088/1742-6596/1137/1/012038⟩. ⟨hal-01982823⟩
    • Jean-Marc Richard, Alfredo Valcarce, Javier Vijande. Doubly-heavy baryons, tetraquarks, and related topics. Mini-Workshop Bled 2018, Jun 2018, Bled, Slovenia. pp.24. ⟨hal-01937670⟩
    • Ilaria Rinaldi, Ludovic de Marzi, Annalisa Patriarca, Giuseppe Pitta, Nils Krah. High WET resolution proton radiography using dedicated image processing methods and a commercial plug'n'play detector. Proton Imaging Workshop Lyon 2018, Jun 2018, Lyon, France. ⟨hal-02048584⟩
    • Nils Krah. A comprehensive theoretical comparison of proton imaging set-ups in terms of spatial resolution. Proton Imaging Workshop Lyon 2018, Jun 2018, Lyon, France. ⟨hal-02048546⟩
    • Yasmine Ali, Michael Beuve, A. Carnicer, E. Debiton, F. Degoul, et al.. Simulation de la dose biologique produite par des protons de 65 MeV (faisceau clinique) et des ions carbone. congrès de la Société Française de Physique Médicale, Jun 2018, Toulouse, France. ⟨hal-02083082⟩
    • Yazid Touileb, Hamid Ladjal, Michael Beuve, Behzad Shariat. Particle-beam-dependent optimization for Monte Carlo simulation in hadrontherapy using tetrahedral geometries. Physics in Medicine and Biology, 2018, 63 (13), pp.135021. ⟨10.1088/1361-6560/aacbe5⟩. ⟨hal-01821168⟩
    • Ralf Kohley, Luca Conversi, Pierre-Elie Crouzet, Paolo Strada, Rémi Barbier, et al.. Random telegraph signal (RTS) in the Euclid IR H2RGs. SPIE Astronomical Telescopes + Instrumentation 2018, Jun 2018, Austin, United States. pp.107091G, ⟨10.1117/12.2312434⟩. ⟨hal-01959777⟩
    • Aurélia Secroun, Jean-Claude Clémens, Anne Ealet, William Gillard, Benoît Serra, et al.. Euclid flight H2RG IR detectors: per pixel conversion gain from on-ground characterization for the Euclid NISP instrument. SPIE Astronomical Telescopes + Instrumentation 2018, Jun 2018, Austin, United States. pp.1070921, ⟨10.1117/12.2312518⟩. ⟨hal-01959780⟩
    • Pierre-Elie Crouzet, Paolo Strada, Ralf Kohley, Remi Barbier, Brian Shortt, et al.. Euclid H2RG detectors: Impact of crosshatch patterns on photometric and centroid errors. SPIE Astronomical Telescopes + Instrumentation 2018, Jun 2018, Austin, United States. pp.107090Q, ⟨10.1117/12.2312692⟩. ⟨hal-02097420⟩

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