Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Mariel E. Galassi, Veronica Tessaro, Benoit Gervais, Michael Beuve. Multiple ionization cross sections for swift ion impact on ne-like molecules. 10TH INTERNATIONAL SYMPOSIUM ON SWIFT HEAVY IONS IN MATTER & 28TH INTERNATIONAL CONFERENCE ON ATOMIC COLLISIONS IN SOLIDS - SHIM-ICACS 2018, Jul 2018, Caen, France. 2018. ⟨hal-01875650⟩
  • Veronica Tessaro, Mariel E. Galassi, Benoit Gervais, Michael Beuve. A single method to calculate multiple ionization cross sections of Air molecules by ion impact. 10TH INTERNATIONAL SYMPOSIUM ON SWIFT HEAVY IONS IN MATTER & 28TH INTERNATIONAL CONFERENCE ON ATOMIC COLLISIONS IN SOLIDS - SHIM-ICACS 2018, Jul 2018, Caen, France. ⟨hal-01875673⟩
  • N. Krah, Feriel Khellaf, Jean Michel Létang, S. Rit, I. Rinaldi. A comprehensive theoretical comparison of proton imaging set-ups in terms of spatial resolution. Physics in Medicine and Biology, 2018, 63 (13), ⟨10.1088/1361-6560/aaca1f⟩. ⟨hal-01909706⟩
  • Veronica Tessaro, Floriane Poignant, Michael Beuve, Benoit Gervais, Mariel E. Galassi. Theoretical study of W-values for particle impact on vapour and liquid water. 10TH INTERNATIONAL SYMPOSIUM ON SWIFT HEAVY IONS IN MATTER & 28TH INTERNATIONAL CONFERENCE ON ATOMIC COLLISIONS IN SOLIDS - SHIM-ICACS 2018, Jul 2018, Caen, France. ⟨hal-01875665⟩
  • Julien Billard. Searching for Low-Mass Dark Matter with Cryogenic Detectors. The 14th International Workshop Dark Side Of the Universe, Jun 2018, Annecy, France. ⟨hal-02060200⟩
  • Z. Citron, A. Dainese, J.F. Grosse-Oetringhaus, J.M. Jowett, Y.-J. Lee, et al.. Future physics opportunities for high-density QCD at the LHC with heavy-ion and proton beams. HL/HE-LHC Workshop, Jun 2018, Geneva, Switzerland. ⟨hal-01974840⟩
  • A. Valcarce, J.-M. Richard, J. Vijande. Basics of doubly heavy tetraquarks. 13th International Conference on Beauty, Charm and Hyperons, Jun 2018, Peniche, Portugal. pp.012038, ⟨10.1088/1742-6596/1137/1/012038⟩. ⟨hal-01982823⟩
  • Jean-Marc Richard, Alfredo Valcarce, Javier Vijande. Doubly-heavy baryons, tetraquarks, and related topics. Mini-Workshop Bled 2018, Jun 2018, Bled, Slovenia. pp.24. ⟨hal-01937670⟩
  • Ilaria Rinaldi, Ludovic de Marzi, Annalisa Patriarca, Giuseppe Pitta, Nils Krah. High WET resolution proton radiography using dedicated image processing methods and a commercial plug'n'play detector. Proton Imaging Workshop Lyon 2018, Jun 2018, Lyon, France. ⟨hal-02048584⟩
  • Nils Krah. A comprehensive theoretical comparison of proton imaging set-ups in terms of spatial resolution. Proton Imaging Workshop Lyon 2018, Jun 2018, Lyon, France. ⟨hal-02048546⟩

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