Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • M. Giffon. Polarization parameters and reconstruction of amplitudes for \pi-N scattering. Il Nuovo Cimento A, 1972, 7, pp.705. ⟨in2p3-00010589⟩
  • P. Desgrolard, T.F. Hammann. Transition operator for a matrix potential: an application to the pion-nucleon interaction. Physical Review C, 1972, 8, pp.888-895. ⟨in2p3-00010683⟩
  • P. Desgrolard, T.F. Hammann. Pion-nucleon potentials for use in low energy nuclear physics. Physical Review C, 1972, 6, pp.482-486. ⟨in2p3-00010682⟩
  • Bernard Ille. Etude de l'interaction dans l'etat final entre le proton et le neutron issus des reactions ^1H(d,pn)^1H, ^2H(d,pn)^2H, ^3He(d,pn)^3He, ^4He(d,pn)^4He. Physique NuclĂ©aire ExpĂ©rimentale [nucl-ex]. UniversitĂ© Claude Bernard - Lyon I, 1971. Français. ⟨NNT : ⟩. ⟨tel-00743585⟩
  • A. Cachard, J. Pivot, A. Roger, M. Talvat, J.-P. Thomas. Analyse stĹ“chiomĂ©trique de couches Ă©vaporĂ©es d'oxyde de silicium par observation simultanĂ©e des rĂ©actions nuclĂ©aires (d, p) sur l'oxygène et le silicium. Revue de Physique AppliquĂ©e, 1971, 6 (3), pp.279-283. ⟨10.1051/rphysap:0197100603027900⟩. ⟨jpa-00243542⟩
  • J. Giroux, M. Talvat, J.-P. Thomas. Contribution au dosage de l'oxygene dans le silicium au moyen de particules alpha. Bulletin de la Societe Chimique de France, 1971, 2, pp.706. ⟨in2p3-00008263⟩
  • C. Meynadier, A. Dauchy, D. Drain. Étude de quelques Ă©tats excitĂ©s de 41a par la rĂ©action 40a(d, pÎł) 41A. Journal de Physique, 1971, 32 (4), pp.225-230. ⟨10.1051/jphys:01971003204022500⟩. ⟨jpa-00207048⟩
  • M. Giffon. Operateurs integraux equations integrales et applications physiques. 1971. ⟨in2p3-00011234⟩
  • M. Giffon, J. Joseph, J. Meyer. Reconstruction of amplitudes from experimental data. Il Nuovo Cimento A, 1971, 5, pp.478. ⟨in2p3-00010591⟩
  • M. Brossard, J. Combe, Jean Fain, J. Gardes, L. Meritet, et al.. Utilisation de telescopes a semiconducteurs pour la detection des noyaux de recul dans des experiences de diffusion coherente proton-noyau leger a haute energie. Nuclear Instruments and Methods, 1971, 93, pp.529-534. ⟨10.1016/0029-554X(71)90077-2⟩. ⟨in2p3-00013339⟩

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