Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • B. Chambon, D. Drain, G. Elayi, M.J. Gaillard, M. Lambert, et al.. Study of 5.69- and 5.78-MeV states in ^{21}Ne through the ^{20}Ne(dp) ^{21}Ne reaction. Physical Review C, 1974, 9, pp.422-425. ⟨in2p3-00013338⟩
  • J.-P. Thomas, L. Porte, J. Engerran, J-C. Viala, J. Tousset. Thin layers composition and impurities determination using low energy proton X-ray excitation. Nuclear Instruments and Methods, 1974, 117, pp.579. ⟨in2p3-00008268⟩
  • P. Desgrolard, P. Midy. Corrected expressions of the electromagnetic transitions in the \epsilon- representation of the Nilsson model. Physics Letters B, 1974, 52, pp.169-171. ⟨in2p3-00010685⟩
  • J. Giroux, J.-P. Thomas. Le dosage de l'oxygene au moyen de particules chargees dans le silicium et le germanium - Mises au point relatives aux reactions parasites et a l'isolement du fluor-18. Journal of Radioanalytical Chemistry, 1974, 19, pp.129. ⟨in2p3-00008271⟩
  • J.-P. Thomas, J. Engerran, A. Cachard, J. Tardy. A telescope counter detection system applied to low-energy ion-beam surface analysis. Nuclear Instruments and Methods, 1974, 119, pp.373. ⟨in2p3-00008270⟩
  • J. Danière, R. Rougny, E. Descroix, Daniel Charnay, Roland Billerey, et al.. DÉTERMINATION DE VIES MOYENNES Ă€ L'AIDE D'UN CORRÉLATEUR DIGITAL EN TEMPS RÉEL. Nuclear Instruments and Methods, 1974, 115, pp.165-171. ⟨hal-01109240⟩
  • Robert Beraud. Etude spectroscopique des isotopes ^{202}Hg ^{200}Hg ^{198}Hg et ^{196}Hg. Physique NuclĂ©aire ExpĂ©rimentale [nucl-ex]. UniversitĂ© Claude Bernard - Lyon I, 1973. Français. ⟨NNT : ⟩. ⟨tel-00794610⟩
  • M. Cohen, L. Porte, J.-P. Thomas, J. Tousset. Analyse de couches minces de verres chalcogenures par diffusion elastique de protons et mesure de gammas prompts. Journal of Radioanalytical and Nuclear Chemistry, 1973, 17, pp.65-77. ⟨in2p3-00013345⟩
  • M. Lambert, P. Midy, P. Desgrolard. A study of even-odd nuclei with N or Z= 11 or 13. Physical Review C, 1973, 8, pp.1728-1755. ⟨in2p3-00010684⟩
  • M. Bedjidian. Etude du transfert d'un agrĂ©gat alpha par des rĂ©actions (d ^6Li) sur quelques noyaux lĂ©gers. Physique NuclĂ©aire ExpĂ©rimentale [nucl-ex]. UniversitĂ© Claude Bernard - Lyon I, 1972. Français. ⟨NNT : ⟩. ⟨tel-00751399⟩

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