Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • R. Béraud, C. Bourgeois, M. Desthuilliers, P. Kilcher, Jocelyne Letessier. ÉTUDE EN LIGNE SUR ISOCÈLE DE LA DÉSINTÉGRATION 186Tl → 186Hg. Colloquium on Nuclear Surface, 1975, Dijon, France. pp.C5-101-C5-103, ⟨10.1051/jphyscol:1975520⟩. ⟨jpa-00216375⟩
  • A. Emsallem, M. Asghar. The (n_{th}\alpha) reaction on ^{95}Mo ^{123}Te and ^{145}Nd. Zeitschrift für Physik. A, Atoms and Nuclei, 1975, 275, pp.157-161. ⟨in2p3-00013346⟩
  • B. Chambon, P. Desgrolard, D. Drain, M. Lambert, N. Persehaye. Elastic and inelastic proton scattering on ^{21}Ne and T=1 states of ^{22}Na. Physical Review C, 1975, 12, pp.1-13. ⟨in2p3-00010686⟩
  • J.-R. Pizzi. DIFFUSION QUASI ÉLASTIQUE. Colloquium on Nuclear Surface, 1975, Dijon, France. pp.C5-63-C5-67, ⟨10.1051/jphyscol:1975509⟩. ⟨jpa-00216364⟩
  • J.-M. Mackowski. Detection of heavy charged particles with amorphous track detectors. One-Day Meeting For Studying Nuclear Detectors, Oct 1974, Grenoble, France. pp.75-80. ⟨in2p3-00013435⟩
  • A. Emsallem, M. Asghar. The (n_{th} \alpha) and (n_{th} \gamma \alpha) reactions on ^{143}Nd ^{149}Sm and ^{147}Sm.. International Symposium On Neutron Capture Gamma Ray Spectroscopy And Related Topics 2, Sep 1974, Petten, Netherlands. pp.395-400. ⟨in2p3-00004073⟩
  • J. Remillieux. Transmission of fast molecules through solids. International Radiation Research Congress Meeting 5, Jul 1974, Seattle, United States. pp.302-314. ⟨in2p3-00013439⟩
  • Daniel Charnay, J. Danière, E. Descroix, R. Rougny. CORRELATEUR DIGITAL D'IMPULSIONS, APPLICATION A L’ÉTUDE DE NIVEAUX NUCLÉAIRES DE VIE MOYENNE COMPRISE ENTRE 1 micro seconde ET 1 seconde.. GUTS-URSI-SEE, CEA - Centre d'études nucléaires de Grenoble, LETI, Apr 1974, Grenoble, France. pp.180. ⟨hal-01437877⟩
  • B. Chambon, D. Drain, G. Elayi, M.J. Gaillard, M. Lambert, et al.. Study of 5.69- and 5.78-MeV states in ^{21}Ne through the ^{20}Ne(dp) ^{21}Ne reaction. Physical Review C, 1974, 9, pp.422-425. ⟨in2p3-00013338⟩
  • J.-P. Thomas, L. Porte, J. Engerran, J-C. Viala, J. Tousset. Thin layers composition and impurities determination using low energy proton X-ray excitation. Nuclear Instruments and Methods, 1974, 117, pp.579. ⟨in2p3-00008268⟩

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