Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    8791 documents

    • J.-Y. Grossiord, M. Bedjidian, A. Guichard, M. Gusakow, J.-R. Pizzi, et al.. ÉTUDE DES RÉACTIONS (p, pd), (p, pt) ET (p, p 3He) SUR 12C ET 16O A 75 MeV. Colloquium on Nuclear Surface, 1975, Dijon, France. pp.C5-123-C5-125, ⟨10.1051/jphyscol:1975531⟩. ⟨jpa-00216386⟩
    • D. Drain, B. Chambon, Y. Chanut, P. Desgrolard. On ^{21}Na states between E_x = 5.5 and 6.2 MeV. Zeitschrift für Physik. A, Atoms and Nuclei, 1975, 274, pp.353-358. ⟨in2p3-00014841⟩
    • J.-P. Thomas, J. Gréa. Large-depth concentration profile determination using -rays proton-induced reactions. Nuclear Instruments and Methods, 1975, 126, pp.303. ⟨in2p3-00008272⟩
    • E. Elbaz, R. Nahabetian, J. Meyer. Two-nucleon transfer reactions between heavy ions. Il Nuovo Cimento A, 1975, 28, pp.305-320. ⟨in2p3-00004043⟩
    • J.-R. Pizzi. DIFFUSION QUASI ÉLASTIQUE. Colloquium on Nuclear Surface, 1975, Dijon, France. pp.C5-63-C5-67, ⟨10.1051/jphyscol:1975509⟩. ⟨jpa-00216364⟩
    • R. Béraud, C. Bourgeois, M. Desthuilliers, P. Kilcher, Jocelyne Letessier. ÉTUDE EN LIGNE SUR ISOCÈLE DE LA DÉSINTÉGRATION 186Tl → 186Hg. Colloquium on Nuclear Surface, 1975, Dijon, France. pp.C5-101-C5-103, ⟨10.1051/jphyscol:1975520⟩. ⟨jpa-00216375⟩
    • A. Emsallem, M. Asghar. The (n_{th}\alpha) reaction on ^{95}Mo ^{123}Te and ^{145}Nd. Zeitschrift für Physik. A, Atoms and Nuclei, 1975, 275, pp.157-161. ⟨in2p3-00013346⟩
    • J.-P. Thomas, J. Engerran, J. Tousset. Analyse par observation directe de reactions nucleaires de l'oxygene et du carbone au voisinage de la surface d'echantillons de bore. Journal of Radioanalytical and Nuclear Chemistry, 1975, 25, pp.163-177. ⟨in2p3-00007747⟩
    • B. Chambon, P. Desgrolard, D. Drain, M. Lambert, N. Persehaye. Elastic and inelastic proton scattering on ^{21}Ne and T=1 states of ^{22}Na. Physical Review C, 1975, 12, pp.1-13. ⟨in2p3-00010686⟩
    • Georgette Delibrias, Jacques Évin. Sommaire des datations 14 C concernant la préhistoire en France [ I. — Dates parues de 1955 à 1974 (suite)]. Bulletin de la Société préhistorique française, 1975, 72 (3), pp.93 - 96. ⟨10.3406/bspf.1975.8357⟩. ⟨hal-03407101⟩

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