Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8788 documents

  • A. Charvet, R. Duffait, T. Negadi, A. Emsallem, G. Marguier, et al.. Lifetimes of levels in ^{64}Zn from doppler shift measurements via the ^{61}Ni (\alpha n) ^{64}Zn reaction. Physical Review C, 1976, 13, pp.2237-2240. ⟨in2p3-00023053⟩
  • A. Guichard, W. Benenson, R.G. Markham, H. Nann. ^{48}Ti (p ^3He) ^{46}Sc reaction. Physical Review C, 1976, 13, pp.540-547. ⟨in2p3-00009371⟩
  • J. Tousset, J.-P. Thomas, A. Cachard. Alpha-particle and lithium-ion backscattering: complementary methods for surface analysis. International Nuclear And Atomic Activation Analysis Conference And Annual Meeting On Analytical Chemistry In Nuclear Technology. 19, Oct 1975, Gatlinburg, United States. pp.11. ⟨in2p3-00004080⟩
  • M.J. Gaillard, J.-C. Poizat, J. Remillieux, A. Chateau-Thierry, A. Gladieux, et al.. Neutral fraction in proton beams after channeling through thin crystals. International Conference On Atomic Collisions In Solids 6, Sep 1975, Amsterdam, Netherlands. pp.547-551. ⟨in2p3-00023047⟩
  • M.J. Gaillard, J.-C. Poizat, A. Ratkowski, J. Remillieux. The dependence of H_2^+ molecular-ion yields on the proton neutral fraction. International Conference On Atomic Collisions In Solids 6, Sep 1975, Amsterdam, Netherlands. pp.69-73. ⟨in2p3-00023043⟩
  • R. Haroutunian, G. Marest, I. Berkes. Nuclear orientation of 5 h lifetime ^{110}_{49}In. International Meeting On Hyperfine Interactions, Sep 1975, Leuven, Belgium. pp.306-307. ⟨in2p3-00013402⟩
  • I. Berkes, R. Haroutunian, G. Marest. Magnetic moments of few-hours lifetime ^{93,94}Tc nuclei. International Meeting On Hyperfine Interactions, Sep 1975, Leuven, Belgium. pp.297-298. ⟨in2p3-00004672⟩
  • P. Haensel, J. Meyer. The equation of state and the magnetic susceptibility of neutron matter with realistic n-n potentials.. International Conference On Nuclear Self-Consistent Fields, Feb 1975, Trieste, Italy. pp.153. ⟨in2p3-00004072⟩
  • M. Giffon. Une tentative de reconstruction directe de la matrice de diffusion pp en dessous de 500 MeV. Session d'Etudes Biennale de Physique Nucleaire 3, Feb 1975, La Toussuire, France. ⟨in2p3-00010627⟩
  • M. Chartoire, J. Engerran, J.-P. Thomas, J. Tousset. A target chamber designed for adsorption studies using charged-particles-induced nuclear reactions. Thin Solid Films, 1975, 30, pp.311. ⟨in2p3-00018914⟩

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