Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8791 documents

    • M. Meyer, J. Daniere, J. Letessier, P. Quentin. A self consistent approach to the deformation properties of silver cadmium and indium isotopes. European Conference on Nuclear Physics with Heavy Ions, Sep 1976, Caen, France. pp.98. ⟨in2p3-00004118⟩
    • M. Ericson. Pion field and weak interactions in nuclei. Mesonic Interface Between Nuclear Structure And Particle Physics, Sep 1976, Erice, Italy. pp.67-104. ⟨in2p3-00004882⟩
    • R. Billerey, C. Cerruti, A. Chevarier, N. Chevarier, A. Demeyer. Structure effects in heavy ion cross section. European Conference On Nuclear Physics With Heavy Ions, Sep 1976, Caen, France. pp.128. ⟨in2p3-00004036⟩
    • M. Kibler. Group theory around ligand field theory. International Colloquium on Group Theoretical Methods in Physics 5, Jul 1976, Montreal, Canada. pp.161-172. ⟨in2p3-00008102⟩
    • P. Baillon, C. Bricman, Y. Déclais, J. Duchon, M. Ferro-Luzzi, et al.. The k-n elastic differential cross section between 1.2 and 2.2 GeV/c. Topical Conference on Baryon Resonances, Jul 1976, Oxford, United Kingdom. pp.327-337. ⟨in2p3-00003104⟩
    • M. Ericson. Axial polarizability and weak currents in nuclei. Topical Conference On Weak Interactions, Jun 1976, Brighton, United Kingdom. pp.173-181. ⟨in2p3-00004875⟩
    • J. Delorme, M. Ericson, A. Figureau, C. Thevenet. Axial polarizability and pionic field in nuclei. International Topical Conference On Meson-Nuclear Physics, May 1976, Pittsburgh, United States. pp.190-191. ⟨in2p3-00004489⟩
    • A. Figureau, N.C. Makhopadhyay. Excitation of the carbon-14 ground state by the charged pion photoproduction at threshold in nitrogen-14. International Topical Conference On Meson-Nuclear Physics, May 1976, Pittsburgh, United States. pp.616-619. ⟨in2p3-00022935⟩
    • G. Andersson, M. Asghar, A. Emsallem, E. Hagberg, B. Jonson. Observation of proton emission following thermal neutron capture in 34.5 D ^{84}Rb. Physics Letters B, 1976, 61, pp.234-236. ⟨in2p3-00013461⟩
    • J. Delorme, M. Ericson, A. Figureau, C. Thevenet. Axial polarizability and weak currents in nuclei. Annals of Physics, 1976, 102, pp.273-322. ⟨10.1016/0003-4916(76)90264-5⟩. ⟨in2p3-00004355⟩

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