Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- M. Benmalek, J.M. Mackowski, J. Tousset. Caractérisation électrique de films amorphes de As50Te 50 irradiés par des ions lourds. Revue de Physique Appliquée, 1977, 12 (5), pp.707-710. ⟨10.1051/rphysap:01977001205070700⟩. ⟨jpa-00244230⟩
- J. Genevey-Rivier, A. Charvet, G. Marguier, C. Richard-Serre, J. d'Auria, et al.. Level structure of light even xenon nuclei populated in the decays of isomeric and ground states of
Cs. Nuclear Physics A, 1977, 283, pp.45-63. ⟨10.1016/0375-9474(77)90698-4⟩. ⟨in2p3-00013421⟩ - R. Béraud, M. Meyer, M.G. Desthuilliers, C. Bourgeois, P. Kilcher, et al.. Band crossing in
Hg. Nuclear Physics A, 1977, 284, pp.221-238. ⟨in2p3-00004099⟩ - Phuoc Do Huu, A. Charvet, R. Duffait, R. Chéry. Energy levels of
Br from (pn 
) reactions. Zeitschrift für Physik. A, Atoms and Nuclei, 1977, 282, pp.321-331. ⟨in2p3-00013454⟩ - S. Marsaud, J.-P. Thomas, M. Fallavier, J.-M. Mackowski, J. Tousset. Backscattering analysis of the thermal diffusion of gold layers into amorphous semiconductor thin films. International Conference On Modern Trends In Activation Analysis, Sep 1976, Muenchen, Germany. pp.43-49. ⟨in2p3-00004061⟩
- M. Meyer, J. Daniere, J. Letessier, P. Quentin. A self consistent approach to the deformation properties of silver cadmium and indium isotopes. European Conference on Nuclear Physics with Heavy Ions, Sep 1976, Caen, France. pp.98. ⟨in2p3-00004118⟩
- M. Ericson. Pion field and weak interactions in nuclei. Mesonic Interface Between Nuclear Structure And Particle Physics, Sep 1976, Erice, Italy. pp.67-104. ⟨in2p3-00004882⟩
- R. Billerey, C. Cerruti, A. Chevarier, N. Chevarier, A. Demeyer. Structure effects in heavy ion cross section. European Conference On Nuclear Physics With Heavy Ions, Sep 1976, Caen, France. pp.128. ⟨in2p3-00004036⟩
- M. Kibler. Group theory around ligand field theory. International Colloquium on Group Theoretical Methods in Physics 5, Jul 1976, Montreal, Canada. pp.161-172. ⟨in2p3-00008102⟩
- P. Baillon, C. Bricman, Y. Déclais, J. Duchon, M. Ferro-Luzzi, et al.. The k-n elastic differential cross section between 1.2 and 2.2 GeV/c. Topical Conference on Baryon Resonances, Jul 1976, Oxford, United Kingdom. pp.327-337. ⟨in2p3-00003104⟩
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