Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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- DOCTORANTS / DOCTORAL STUDENTS:
    8791 documents

    • J. Meyer, R. Nahabetian, E. Elbaz. Optical-model analysis of vector polarized ^6Li elastic scattering on ^{12}C ^{16}O ^{28}Si and ^{58}Ni nuclei. Lettere al Nuovo Cimento Della Societa Italiana di Fisica, 1978, 22, pp.355-359. ⟨in2p3-00015080⟩
    • M. Fallavier, J.-P. Thomas. Limitations dans l'analyse de surface par faisceaux d'ions d'aluminium raffine. Le Vide les Couches Minces, 1978, 189, pp.17. ⟨in2p3-00008273⟩
    • M. Lambert, J.-P. Thomas, J.P. Buchet. Adaption of an alkali metal ion source on a low-energy vdg-type electrostatic accelerator. International Conference On Low-Energy Ion Beams 1, Sep 1977, Salford, United Kingdom. pp.103-108. ⟨in2p3-00004075⟩
    • E. Elbaz, C. Fayard, G.-H. Lamot. Three-body treatment of (d- \alpha) elastic scattering. International Conference On Nuclear Structure, Sep 1977, Tokyo, Japan. pp.304-310. ⟨in2p3-00004222⟩
    • K. Kubodera, J. Delorme, M. Rho. Second class currents and nuclei. International Conference On Nuclear Structure, Sep 1977, Tokyo, Japan. pp.465-469. ⟨in2p3-00004361⟩
    • M. Giffon, P.A.M. Guichon, L. Joseph, C. Samour. Exchange corrections for partial capture rates of muons in nuclei. International Conference on High Energy Physics and Nuclear Structure 7, Aug 1977, Zurich, Switzerland. ⟨in2p3-00010628⟩
    • M. Giffon, P.A.M. Guichon, B. Bihoreau, A. Goncalves, J. Julien, et al.. Partial \mu capture in ^{16}O. International Conference on High Energy Physics and Nuclear Structure 7, Aug 1977, Zurich, Switzerland. ⟨in2p3-00010629⟩
    • J. Remillieux. Interaction of swift molecular ions with thin solid targets.. International Conference On The Physics Of Electronic And Atomic Collisions 10, Jul 1977, Paris, France. pp.295-309. ⟨in2p3-00013440⟩
    • J.-P. Thomas, J.-M. Mackowski, J. Tousset. Kinetics of drift and thermal diffusion of gold electrodes into amorphous semiconductor thin films. International Conference On Ion Beam Analysis 3, Jun 1977, Washington, United States. pp.265-269. ⟨in2p3-00004062⟩
    • J.-P. Thomas, M. Fallavier. Lithium ion production and use for backscattering analysis in aluminum and aluminum oxide media. International Conference On Ion Beam Analysis 3, Jun 1977, Washington, United States. pp.169-175. ⟨in2p3-00004063⟩

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