The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

8786 documents

  • N. Cue, N.V. De Castro Faria, M.J. Gaillard, J.-C. Poizat, J. Remillieux. Electron loss and capture cross sections of 800 KeV amu^{-1} H and He species in carbon foils. International Conference On Atomic Collisions In Solids 8, Aug 1979, Hamilton, Canada. pp.67-72. ⟨in2p3-00023041⟩
  • M. Ericson. Nuclear critical opalescence. International Conference On High Energy Physics And Nuclear Structure With The Kaon Workshop - Icohepans 8, Aug 1979, Vancouver, Canada. pp.309-314. ⟨in2p3-00004885⟩
  • J. Remillieux. Interaction of fast molecular ions with solids. International Conference On Atomic Collisions In Solids 8, Aug 1979, Hamilton, Canada. pp.31-40. ⟨in2p3-00023049⟩
  • M. Giffon, P.A.M. Guichon, A. Goncalves, J. Julien, B. Bihoreau, et al.. Partial \mu-capture in ^{10}B and ^{14}N. International Conference on High Energy Physics and Nuclear Structure 8, Aug 1979, Vancouver, Canada. ⟨in2p3-00010624⟩
  • P. Quentin, J. Letessier, M. Meyer, J. Libert, M.G. Desthuilliers-Porquet. A rotor plus quasi-particle approach for soft and deformed odd nuclei. Workshop on the Nuclear Spectroscopy of Fission Products, May 1979, Grenoble, France. pp.280-287. ⟨in2p3-00013181⟩
  • Bernard Ille. Mesures des sections efficaces différentielles de la diffusion élastique pi- p dans la région d'interférence coulombienne entre 30 et 140 GeV. Physique des Hautes Energies - Expérience [hep-ex]. Université Claude Bernard - Lyon I, 1979. Français. ⟨NNT : ⟩. ⟨tel-00752367⟩
  • R. Duffait, R. Béraud, A. Charvet, N. Elas, M. Meyer, et al.. In-beam spectroscopy of the odd-odd ^{108}In nucleus. European Physical Society Nuclear Divisional Conference On The Structure Of Medium-Heavy Nuclei 6, May 1979, Rhodes, Greece. pp.263-264. ⟨in2p3-00007783⟩
  • N. Giraud, G.-H. Lamot, C. Fayard. Approximate treatment of coulomb effects in a \pi d elastic scattering at low energy. International Conference On Meson-Nuclear Physics 2, Mar 1979, Houston, United States. pp.590-591. ⟨in2p3-00004337⟩
  • M. Bedjidian, E. Descroix, J.-Y. Grossiord, A. Guichard, M. Gusakow, et al.. Further evidence for the existence of the \gamma decaying states of ^4_\lambdaH and ^4_\lambda He. International Conference On Meson-Nuclear Physics 2, Mar 1979, Houston, United States. pp.723-724. ⟨in2p3-00013429⟩
  • P.A.M. Guichon, M. Giffon, C. Samour. The problem of exchange currents in the transition: O-16 (0^+) N-16(0). International Topical Conference on Meson Nuclear Physics 2, Mar 1979, Houston, United States. ⟨in2p3-00011236⟩