Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    8791 documents

    • M. Fallavier, J.-P. Thomas, J. Tousset, Y. Monteil, J. Bouix. Hydrogen effusion under 6-7-MeV ^{15}N ions irradiation in oxygen-contaminated thin films of sputtered A-Si:H. Applied Physics Letters, 1981, 39, pp.490-492. ⟨in2p3-00007752⟩
    • M. Giffon, E. Predazzi. On the origin of the leading-particle effect in high-energy hadronic process. Il Nuovo Cimento A, 1981, 62, pp.238-252. ⟨in2p3-00009690⟩
    • J.-P. Burq, M. Chemarin, M. Chevallier, J. Fay, B. Ille, et al.. Measurements of the total \pi -He and p-He cross sections and the slopes of the forward diffraction peak at energies from 50 to 300 GeV. Nuclear Physics B, 1981, 187, pp.205-230. ⟨in2p3-00023000⟩
    • J.-P. Thomas, M. Fallavier, J. Tousset. Hydrogen mobility under beam impact when using the ^1H(^{15}H) nuclear reaction for material analysis. Nuclear Instruments and Methods in Physics Research, 1981, 187, pp.573-580. ⟨in2p3-00007751⟩
    • E. Elbaz. A geometrical approach to elementary particles. Il Nuovo Cimento A, 1981, 63, pp.257-320. ⟨in2p3-00004203⟩
    • A. Emsallem, M. Asghar, C. Wagemans, H. Weigmann. Study of neutron induced charged particle reactions on ^{40}K - Part I. Nuclear Physics A, 1981, 368, pp.108-116. ⟨in2p3-00013478⟩
    • E. Elbaz, J. Meyer. Spin of the diquark from baryon magnetic moments. Lettere al Nuovo Cimento Della Societa Italiana di Fisica, 1981, 31, pp.291-297. ⟨in2p3-00004096⟩
    • J. Delorme, A. Figureau, P.A.M. Guichon. Nuclear critical opalescence and the m1 form factors of ^{12}C and ^{13}Cc. Physics Letters B, 1981, 99, pp.187-190. ⟨in2p3-00004397⟩
    • M. Ericson, A. Figureau. The axial polarizability of nucleons and nuclei. Journal of Physics G Nuclear Physics, 1981, 7, pp.1197-1202. ⟨10.1088/0305-4616/7/9/011⟩. ⟨in2p3-00022868⟩
    • M.N. Namboodiri, P. Gonthier, H. Ho, J.B. Natowitz, R. Eggers, et al.. Emission of light charged particles in the reactions of 120 MeV ^{20}Ne with ^{27}Al. Nuclear Physics A, 1981, 367, pp.313-322. ⟨in2p3-00013398⟩

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