Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8791 documents

    • M. Giffon, E. Predazzi. Highlights in particle physics - On the unification of forces in particle physics. Session d'Etudes Biennale de Physique Nucleaire 6, Feb 1981, Aussois, France. ⟨in2p3-00010621⟩
    • M. Chartoire. Utilisation des methodes nucleaires d'analyse en ultra-vide application au dosage de l'hydrogene dans les solides. Chemical Physics [physics.chem-ph]. Université Claude Bernard - Lyon I, 1981. English. ⟨NNT : ⟩. ⟨in2p3-00015058⟩
    • N. Elias, R. Béraud, A. Charvet, R. Duffait, M. Meyer, et al.. High-spin states in the odd-odd nucleus ^{108}_49}In. Nuclear Physics A, 1981, 351, pp.142-156. ⟨in2p3-00004664⟩
    • J. Sau, K. Heyde. Particle-core coupling for heavy odd-odd and odd-even sb nuclei: a shell model approach. Physical Review C, 1981, 23, pp.2315-2323. ⟨in2p3-00013466⟩
    • M. Giffon, A. Goncalves, P.A.M. Guichon, J. Julien, L. Roussel, et al.. \mu - \partial capture rates in B-10 C-12 and 14-N. Physical Review C, 1981, 24, pp.241-259. ⟨in2p3-00009688⟩
    • G. Marguier, A. Charvet, J. Genevey, C. Richard-Serre, A. Knipper. The decay of 1.7 s ^{123m}Cs and 5.9 min ^{123}Cs. Journal of Physics G Nuclear Physics, 1981, 7, pp.101-113. ⟨10.1088/0305-4616/7/1/014⟩. ⟨in2p3-00013480⟩
    • M. Ericson, P.A.M. Guichon, R.D. Viollier. Nuclear axial polarizability and the \alpha + \alpha interaction. Nuclear Physics A, 1981, 372, pp.377-385. ⟨10.1016/0375-9474(81)90041-5⟩. ⟨in2p3-00004883⟩
    • B. Fogelberg, K. Heyde, J. Sau. Energy levels and transition probabilities in ^{130}Sn. Nuclear Physics A, 1981, 352, pp.157-180. ⟨in2p3-00013465⟩
    • A. Chevarier, N. Chevarier, S. Chiodelli. A high resolution spectrometer used in MeV heavy ion backscattering analysis. Nuclear Instruments and Methods in Physics Research, 1981, 189, pp.525-531. ⟨in2p3-00013397⟩
    • H. Weigmann, C. Wagemans, A. Emsallem, M. Asghar. Study of neutron induced charged particle reactions on ^{40}K - Part II. Nuclear Physics A, 1981, 368, pp.117-134. ⟨in2p3-00013479⟩

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