Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Antoine Camper, Stefano Aghion, Claude Amsler, Massimiliano Antonello, Alexander Belov, et al.. Imaging a positronium cloud in a 1 Tesla. Quantum Technology International Conference 2018, Sep 2018, Paris, France. pp.00004, ⟨10.1051/epjconf/201919800004⟩. ⟨hal-02000014⟩
  • M. Gouzevitch. HH->2b2g production at CMS. Double Higgs production at colliders workshop, Sep 2018, Chicago, United States. ⟨hal-02077047⟩
  • R. Caravita, S. Aghion, C. Amsler, M. Antonello, A. Belov, et al.. The AEgIS experiment at CERN: Probing antimatter gravity. European Nuclear Physics Conference 2018, Sep 2018, Bologna, Italy. pp.123, ⟨10.1393/ncc/i2019-19123-9⟩. ⟨hal-02423708⟩
  • P. Becker, A. Pastore, D. Davesne, J. Navarro. Error analysis of the parameters of the Skyrme N2LO pseudo-potential. European Nuclear Physics Conference 2018, Sep 2018, Bologna, Italy. pp.88, ⟨10.1393/ncc/i2019-19088-7⟩. ⟨hal-01945012⟩
  • G. Jaworski, A. Goasduff, F.J. Egea Canet, V. Modamio, T. Hüyük, et al.. The New Neutron Multiplicity Filter NEDA and Its First Physics Campaign with AGATA. Zakopane Conference on Nuclear Physics, Aug 2018, Zakopane, Poland. pp.585, ⟨10.5506/APhysPolB.50.585⟩. ⟨hal-02123340⟩
  • B. Abi, R. Acciarri, M.A. Acero, M. Adamowski, C. Adams, et al.. The DUNE Far Detector Interim Design Report Volume 1: Physics, Technology and Strategies. 2018. ⟨hal-01862007⟩
  • B. Abi, R. Acciarri, M.A. Acero, M. Adamowski, C. Adams, et al.. The DUNE Far Detector Interim Design Report, Volume 2: Single-Phase Module. 2018. ⟨hal-01861999⟩
  • B. Abi, R. Acciarri, M.A. Acero, M. Adamowski, C. Adams, et al.. The DUNE Far Detector Interim Design Report, Volume 3: Dual-Phase Module. 2018. ⟨hal-01862000⟩
  • T. Haverinen, M. Kortelainen, J. Dobaczewski, K. Bennaceur. Towards a novel energy density functional for beyond-mean-field calculations with pairing and deformation. Zakopane Conference on Nuclear Physics, Aug 2018, Zakopane, Poland. pp.269-274, ⟨10.5506/APhysPolB.50.269⟩. ⟨hal-01937667⟩
  • C. Delafosse, D. Verney, A. Gottardo, F. Ibrahim, S. Franchoo, et al.. Lifetime Measurements Using RDDS Method in the Vicinity of ^{78}Ni. Zakopane Conference on Nuclear Physics, Aug 2018, Zakopane, Poland. pp.633, ⟨10.5506/APhysPolB.50.633⟩. ⟨hal-02116524⟩

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