Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J.-P. Burq, M. Chemarin, M. Chevallier, A.S. Denisov, J. Fay, et al.. Experimental results on pp forward elastic scattering and the possibility of universal shrinkage of the hadronic diffraction cone. Physics Letters B, 1982, 109, pp.124-128. ⟨in2p3-00015209⟩
  • J. Treherne, J. Genevey, A. Gizon, J. Gizon, R. Béraud, et al.. Excited states of n-deficient ^[102}Cd studied via 102 in decay and nuclear reactions. Zeitschrift für Physik. A, Atoms and Nuclei, 1982, 309, pp.135-142. ⟨10.1007/BF01414974⟩. ⟨in2p3-00004106⟩
  • S. Andre, V. Barci, D. Barneoud, H. El-Samman, J. Genevey, et al.. On line gamma-ray emission following 30 MeV/A ^{12}C induced reactions on some medium-heavy targets. Zeitschrift für Physik. A, Atoms and Nuclei, 1982, 308, pp.181-182. ⟨10.1007/BF01413009⟩. ⟨in2p3-00004562⟩
  • J-M. Labouygues, A. Figureau. L'origine et l'evolution du code genetique. Revue Canadienne de Biologie Experimentale, 1982, 41, pp.209-216. ⟨in2p3-00022865⟩
  • K. Heyde, J. Sau, E.A. Henry, R.A. Meyer. Influence of the M1 tensor term for transitions between levels of the two-proton nucleus ^{134}Te populated in the beta decay of 10- ^{134}Sb. Physical Review C, 1982, 25, pp.3193-3196. ⟨in2p3-00013468⟩
  • Ung Chan Tsan, M. Agard, J.F. Bruandet, B. Chambon, A. Dauchy, et al.. High-spin states in ^{60}Cu. Physical Review C, 1982, 26, pp.424-434. ⟨10.1103/PhysRevC.26.424⟩. ⟨in2p3-00005259⟩
  • J. Delorme, A. Figureau, N. Giraud. Pion coupling constants in nuclei and the isobar-holde model. Nuclear Physics A, 1982, 389, pp.509-532. ⟨in2p3-00022869⟩
  • P.A.M. Guichon, C. Samour. Chiral symmetry and axial charge density in the isovector 0^+ \leftrightarrow 1^+ transition in the A = 12 system. Nuclear Physics A, 1982, 382, pp.461-500. ⟨in2p3-00005478⟩
  • J. Blachot, G. Marguier. Nuclear data sheets for A = 114. Nuclear Data Sheets, 1982, 35, pp.375-440. ⟨in2p3-00013423⟩
  • J. Delorme, M. Ericson, P.A.M. Guichon. Quark spin-isospin sum rules and the Adler-Weisberger relation in nuclei. Physics Letters B, 1982, 115, pp.86-90. ⟨in2p3-00004322⟩

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