The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- M. Giffon, Y. Hama, E. Predazzi. Construction of diffractive amplitudes. Zeitschrift für Physik. C, Particles and Fields, 1983, 19, pp.311-320. ⟨in2p3-00009686⟩
- B. Chambon, D. Drain, C. Pastor, A. Dauchy, A. Giorni, et al.. Neutron emission from projectile-like and target-like fragments in the
O +
Ti reaction at E(
O) = 116 MeV. Zeitschrift für Physik. A, Atoms and Nuclei, 1983, 312, pp.125-133. ⟨10.1007/BF01411670⟩. ⟨in2p3-00014842⟩
- M. Kibler, T. Negadi. On the connection between the hydrogen atom and the harmonic oscillator. Lettere al Nuovo Cimento Della Societa Italiana di Fisica, 1983, 37, pp.225-228. ⟨in2p3-00004196⟩
- M. Giffon, E. Predazzi. Quantum mechanics and high-energy physics. Lettere al Nuovo Cimento Della Societa Italiana di Fisica, 1983, 37, pp.430. ⟨in2p3-00009912⟩
- L Dallaire, G. Grenier, Gilles R. Ducharme, M Melancon, M. Potier, et al.. Maternal alphafetoprotein screening by the polypropylene tube immunoradiometric assay on dried blood. Prenatal Diagnosis, 1982, 2 (4), pp.265-71. ⟨10.1002/pd.1970020405⟩. ⟨hal-01832456⟩
- M. Ericson, M. Rosa-Clot. Photonuclear dispersion relation and corrections to the nucleon polarizability in nuclei. Workshop On Medium-Energy Interactions In Nuclear Physics, Sep 1982, Pavia, Italy. pp.180-185. ⟨in2p3-00004326⟩
- A. Perez, J. Bert, G. Marest, B. Sawicka, J. Sawicki. Electrical conductivity modification in iron implanted MGO. International Conference On Ion Beam Modification Of Materials 3, Sep 1982, Grenoble, France. pp.281-287. ⟨in2p3-00004554⟩
- J. Kowalski, J.A. Sawicki, J. Stanek, G. Marest, A. Perez, et al.. Conversion electron moessbauer study of lif implanted with
Fe ions. International Conference On Ion Beam Modification Of Materials 3, Sep 1982, Grenoble, France. pp.1145-1152. ⟨in2p3-00004553⟩
- G. Marest, C. Skoutarides, T. Barnavon, J. Tousset, S. Fayeulle, et al.. Conversion electron Moessbauer spectroscopy and (p
) nuclear reaction studies of
N implanted steels. International Conference On Ion Beam Modification Of Materials 3, Sep 1982, Grenoble, France. pp.259-265. ⟨in2p3-00004552⟩
- A. Perez, G. Marest, P. Gerard, M. Madore, P. Martin. Ion implantation effects in bubble garnet materials. International Conference On Ion Beam Modification Of Materials 3, Sep 1982, Grenoble, France. pp.1179-1185. ⟨in2p3-00004555⟩