Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • I. Berkes, R. Brenier, G. Marest. Low-temperature nuclear orientation of neutron-deficient terbium nuclei. Journal of Physics G Nuclear Physics, 1983, 9, pp.213-226. ⟨in2p3-00004556⟩
  • P.A.M. Guichon, G.A. Miller, A.W. Thomas. The axial form factor of the nucleon and the pion-nucleon vertex function. Physics Letters B, 1983, 124, pp.109-112. ⟨in2p3-00004068⟩
  • J. Meyer, P. Quentin, M. Brack. A sum rule description of giant resonances at finite temperature. Physics Letters B, 1983, 133, pp.279-282. ⟨in2p3-00004085⟩
  • G. Chanfray, J. Delorme. Charged pion electroproduction a selective probe of nuclear spin-isospin responses. Physics Letters B, 1983, 129, pp.167-171. ⟨in2p3-00004356⟩
  • M. Ericson. RECENT ASPECTS OF THE NUCLEAR SPIN ISOSPIN RESPONSE FUNCTION. International Symposium On Highly Excited States And Nuclear Structure ,Hesans 83, 1983, Orsay, France. pp.C4-489-C4-501, ⟨10.1051/jphyscol:1984439⟩. ⟨jpa-00224105⟩
  • M. Giffon, E. Predazzi. Quantum mechanics and high-energy physics. Lettere al Nuovo Cimento Della Societa Italiana di Fisica, 1983, 37, pp.430. ⟨in2p3-00009912⟩
  • L. Luehmann, K.P. Lieb, A. Moussavi-Zarandi, J. Panqueva, J. Sau. Yrast transition strengths in ^{85}Rb and ^{85}Sr. Zeitschrift für Physik. A, Atoms and Nuclei, 1983, 313, pp.297-304. ⟨in2p3-00013475⟩
  • B. Chambon, D. Drain, C. Pastor, A. Dauchy, A. Giorni, et al.. Neutron emission from projectile-like and target-like fragments in the ^{18}O + ^{48}Ti reaction at E(^{18}O) = 116 MeV. Zeitschrift für Physik. A, Atoms and Nuclei, 1983, 312, pp.125-133. ⟨10.1007/BF01411670⟩. ⟨in2p3-00014842⟩
  • M. Giffon, Y. Hama, E. Predazzi. Construction of diffractive amplitudes. Zeitschrift für Physik. C, Particles and Fields, 1983, 19, pp.311-320. ⟨in2p3-00009686⟩
  • M. Kibler, T. Negadi. On the connection between the hydrogen atom and the harmonic oscillator. Lettere al Nuovo Cimento Della Societa Italiana di Fisica, 1983, 37, pp.225-228. ⟨in2p3-00004196⟩

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