Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • M.J. Gaillard, A.G. de Pinho, J.-C. Poizat, J. Remillieux, R. Saoudi. Experimental study of the triatomic hydrogen molecule through the collisional sequence H_3^+ \rightarrow H_3 \rightarrow H_3^+ undergone by fast beams in argon. Physical Review A : Atomic, molecular, and optical physics [1990-2015], 1983, 28, pp.1267-1275. ⟨in2p3-00023039⟩
    • M. Ericson. Gamow-Teller strength near the pion threshold. Physics Letters B, 1983, 120, pp.285-288. ⟨in2p3-00004325⟩
    • R. Coussement, P. Put, L. Hermans, M. Rots, I. Berkes, et al.. Nuclear level mixing resonances on low temperature oriented nuclei. Physics Letters A, 1983, 97, pp.301-304. ⟨in2p3-00004557⟩
    • M. Kibler, T. Negadi. On the connection between the hydrogen atom and the harmonic oscillator: the continuum case. Journal of Physics A: Mathematical and Theoretical, 1983, 16, pp.4265-4268. ⟨in2p3-00004197⟩
    • J. Sau, K. Heyde, J. Van Maldeghem. Shell-model description of very neutron-deficient Pd and Cd nuclei. Nuclear Physics A, 1983, 410, pp.14-28. ⟨in2p3-00013471⟩
    • J.-P. Burq, M. Chemarin, M. Chevallier, A.S. Denisov, C. Dore, et al.. Soft \pi^-p and pp elastic scattering in the energy range 30 to 345 GeV. Nuclear Physics B, 1983, 217, pp.285-335. ⟨in2p3-00013401⟩
    • J. Meyer, P. Quentin, M. Brack. A sum rule description of giant resonances at finite temperature. Physics Letters B, 1983, 133, pp.279-282. ⟨in2p3-00004085⟩
    • G. Chanfray, J. Delorme. Charged pion electroproduction a selective probe of nuclear spin-isospin responses. Physics Letters B, 1983, 129, pp.167-171. ⟨in2p3-00004356⟩
    • M. Ericson. RECENT ASPECTS OF THE NUCLEAR SPIN ISOSPIN RESPONSE FUNCTION. International Symposium On Highly Excited States And Nuclear Structure ,Hesans 83, 1983, Orsay, France. pp.C4-489-C4-501, ⟨10.1051/jphyscol:1984439⟩. ⟨jpa-00224105⟩
    • M. Giffon, E. Predazzi. Quantum mechanics and high-energy physics. Lettere al Nuovo Cimento Della Societa Italiana di Fisica, 1983, 37, pp.430. ⟨in2p3-00009912⟩

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