Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J-M. Labouygues, A. Figureau. The logic of the genetic code : synonyms and optimality against effects of mutations. Origins of life, 1984, 14, pp.685-692. ⟨in2p3-00022867⟩
  • A. Figureau, M. Pouzet. Genetic code and optimal resistance to the effects of mutations. Origins of life, 1984, 14, pp.579-588. ⟨in2p3-00022866⟩
  • M. Kibler, T. Negadi. Connection between the hydrogen atom and the harmonic oscillator: the zero-energy case. Physical Review A : Atomic, molecular, and optical physics [1990-2015], 1984, 29, pp.2891-2894. ⟨in2p3-00004198⟩
  • G. Chanfray. Charged-pion electroproduction and spin-isospin modes in nuclei. Nuclear Physics A, 1984, 429, pp.489-513. ⟨in2p3-00022991⟩
  • P. Jarron, M. Goyot. A fast current sensitive preamplifier (MSD2) for the silicon microstrip detector. European Symposium On Semiconductor Detectors 2 New Developments In Silicon Detectors, Nov 1983, Muenchen, Germany. pp.156-162. ⟨in2p3-00016193⟩
  • M. Meyer. Noyaux loin de la vallée de stabilité excitations individuelles et collectives à basse énergie. École thématique. Ecole Joliot Curie "Structure nucléaire aux frontières de la stabilité", Bombannes, (France), du 12-16 septembre 1983 : 2ème session, 1983. ⟨cel-00638223⟩
  • A. Clouvas, M.J. Gaillard, A.G. De Pinho, J.-C. Poizat, J. Remillieux, et al.. Simultaneous study of non-equilibrated charge and excitation states of MeV/amu light atomic and molecular ions emerging from thin solid targets. International Conference On Atomic Collisions In Solids 10, Jul 1983, Bad Iburg, Germany. pp.273-279. ⟨in2p3-00023037⟩
  • I. Berkes, G. Marest, J. Sau, E.H. Sayouty, P. Put, et al.. The quadrupole moments of ^{195-197} Au^m(11/2) and the low temperature thermal relaxation of gold in cadmium. International Conference On Hyperfine Interactions 6, Jul 1983, Groningen, Netherlands. pp.233-236. ⟨in2p3-00015255⟩
  • I. Berkes, G. Marest, E.H. Sayouty. The sign of the magnetic moment of ^{191}Pt(g.s) determined by moessbauer effect on oriented nuclei. International Conference On Hyperfine Interactions 6, Jul 1983, Groningen, Netherlands. pp.983-986. ⟨in2p3-00015256⟩
  • M. Robelet, J. Tousset, N. Moncoffre, S. Fayeulle, D. Treheux, et al.. Nitrogen ions implantation - manufacturing applications. Colloquium On Metallurgy 26, Jun 1983, Saclay, France. pp.319-322. ⟨in2p3-00004668⟩

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