Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • R. Meissner, C. Lochmann, L. Feketeová. Effectiveness of different isolated nitroimidazoles upon low energy electron interactions,. 7th Annual Center for Molecular Biosciences Innsbruck (CMBI) Meeting 2018, Sep 2018, Grillhof, Vill, Austria. ⟨in2p3-02098149⟩
    • Benedetta Nodari. A 65 nm Data Concentration ASIC for the CMS Outer Tracker Detector Upgrade at HL-LHC. Topical Workshop on Electronics for Particle Physics (TWEPP 2018), Sep 2018, Anvers, Belgium. ⟨hal-02053122⟩
    • Benedetta Nodari, Luigi Caponetto, Geoffrey Christian Galbit, Sebastien Viret, Simone Scarfi. A 65 nm Data Concentration ASIC for the CMS Outer Tracker Detector Upgrade at HL-LHC. Topical Workshop on Electronics for Particle Physics, Sep 2018, Antwerpen, Belgium. pp.099, ⟨10.22323/1.343.0099⟩. ⟨hal-02283547⟩
    • Xiushan Chen, Xueying Lin-Ma, Christophe Combaret, Laurent Mirabito, Guo-Neng Lu, et al.. Improved Tapped-Delay-Line Time-to-Digital Converter with Time-over-Threshold measurement for a new generation of Resistive Plate Chamber detectors. Topical Workshop on Electronics for Particle Physics, Sep 2018, Antwerpen, Belgium. pp.141, ⟨10.22323/1.343.0141⟩. ⟨hal-02283511⟩
    • Bertrand Souères. Supergravities in Superspace. Mathematical Physics [math-ph]. Université de Lyon, 2018. English. ⟨NNT : 2018LYSE1141⟩. ⟨tel-01998725⟩
    • Simone Scarfì, Alessandro Caratelli, Luigi Caponetto, Davide Ceresa, Geoffrey Galbit, et al.. A System-Verilog Verification Environment for the CIC Data Concentrator ASIC of the CMS Outer Tracker Phase-2 Upgrades. Topical Workshop on Electronics for Particle Physics, Sep 2018, Antwerpen, Belgium. pp.097, ⟨10.22323/1.343.0097⟩. ⟨hal-02283546⟩
    • D. Contardo. Future Collider Detectors and Technology. 2018 LHC days in Split, Sep 2018, Split, Croatia. ⟨hal-02063886⟩
    • M. R. Kibler. On the use of Galois fields and Galois rings in quantum information. 20th International Workshop on Computer Algebra in Scientific Computing (CASC 2018), Sep 2018, Lille, France. ⟨hal-02063754⟩
    • A. Pulcini, E. Vardaci, E.M. Kozulin, M. Ashaduzzaman, C. Borcea, et al.. Fission and Quasi-Fission Dynamics Near the Coulomb Barrier: \gamma Rays as Probe for their Timescale. 9th International Symposium on EXOtic Nuclei (EXON 2018), Sep 2018, Petrozavodsk, Russia. pp.330-337, ⟨10.1142/9789811209451_0045⟩. ⟨hal-02463015⟩
    • Romain Graziani. Modélisation Bayésienne des mesures de vitesses particulières dans le projet CosmicFlows. Cosmologie et astrophysique extra-galactique [astro-ph.CO]. Université de Lyon, 2018. Français. ⟨NNT : 2018LYSE1143⟩. ⟨tel-02068966v2⟩

    Powered by HAL logo