Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- M. Ericson, A.W. Thomas. Evidence for an enhanced nuclear sea from the proton-nucleus Drell-Yan process. Physics Letters B, 1984, 148, pp.191-193. ⟨in2p3-00004069⟩
- M. Kibler, T. Negadi. On the use of nonbijective canonical transformations in chemical physics. Croatica Chemica Acta, 1984, 57, pp.1509-1523. ⟨in2p3-00008103⟩
- M. Kibler, T. Negadi. Hydrogen atom in a uniform electromagnetic field as an anharmonic oscillator. Lettere al Nuovo Cimento Della Societa Italiana di Fisica, 1984, 39, pp.319-323. ⟨in2p3-00004199⟩
- G. Chanfray, O. Nachtmann, H.J. Pirner. A color dielectric model for the nucleus. Physics Letters B, 1984, 147, pp.249-252. ⟨in2p3-00022993⟩
- S. Leray, G. Nebbia, C. Gregoire, G. La Rana, P. Lhenoret, et al.. Investigation of the
Ar+
Au, 
U systems at 44 MeV/u. Nuclear Physics A, 1984, 425, pp.345-353. ⟨in2p3-00020568⟩ - M. Giffon, Y. Hama, E. Predazzi. Multiparticle unitarity and diffractive amplitudes. Zeitschrift für Physik. C, Particles and Fields, 1984, 25, pp.129-146. ⟨in2p3-00009689⟩
- A. Goursot, H. Chermette, E. Penigault, M. Chanon, W.L. Waltz. X alpha method as a tool for structure elucidation of short-lived transients generated by pulse radiolysis or flash photolysis Part I - Reductive reactions of PTCL
. Inorganic Chemistry, 1984, 23, pp.3618-3625. ⟨in2p3-00013415⟩ - B. Roussiere, P. Kilcher, J. Sauvage-Letessier, C. Bourgeois, R. Béraud, et al.. Decays of
In and 
In. Nuclear Physics A, 1984, 419, pp.61-76. ⟨10.1016/0375-9474(84)90285-9⟩. ⟨in2p3-00004123⟩ - B. Badelek, M. Chevallier, G. Faeldt, A. Hallgren. Pion-helium elastic scattering at 5 GeV/C. Physica Scripta, 1984, 29, pp.207-215. ⟨in2p3-00009512⟩
- D. Guinet, R. Billerey, C. Cerruti, S. Chiodelli, A. Demeyer. Projectile fragmentation processes in 30 MeV/amu (
N light particles Hi) reactions. Physics Letters B, 1984, 137, pp.318-322. ⟨in2p3-00013357⟩
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