Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Delorme, M. Ericson, A. Figureau. Lorentz-Lorentz quenching for the Gamow-Teller sum rule. Journal of Physics G Nuclear Physics, 1985, 11, pp.343-349. ⟨10.1088/0305-4616/11/3/012⟩. ⟨in2p3-00004316⟩
  • M. Morjean, J.-L. Charvet, J.L. Uzureau, Y. Patin, A. Peghaire, et al.. Nuclear fragmentation processes in the ^{20}Ne + ^{27}Al system at 30 MeV/a. Nuclear Physics A, 1985, 438, pp.547-563. ⟨in2p3-00015079⟩
  • P.E. Filpus-Luyckx, J.-P. Thomas, M. Fallavier, E.A. Schweikert. Desorption mass spectrometry using cluster ions. International Conference on the Application of Accelerators in Research and Industry 8, Nov 1984, Denton, United States. pp.751-753. ⟨in2p3-00004071⟩
  • M. Kibler, T. Negadi, A. Ronveaux. The Kustaanheimo-Stiefel transformation and certain special functions. Laguerre Symposium, Oct 1984, Bar-Le-Duc, France. pp.497-505. ⟨in2p3-00003919⟩
  • T. Barnavon, H. Jaffrezic, G. Marest, N. Moncoffre, J. Tousset, et al.. Influence of temperature on nitrogen-implanted steels and iron. International Conference On Surface Modification Of Metals By Ion Beams, Sep 1984, Heidelberg, Germany. pp.531-537. ⟨in2p3-00013383⟩
  • M. Ericson. Effet EMS et pions dans les noyaux. École thématique. Ecole Joliot Curie "Mésons, baryons, quarks et physique nucléaire", Bombannes, (France), du 17-21 septembre 1984 : 3ème session, 1984. ⟨cel-00640931⟩
  • P. Put, R. Coussement, G. Scheveneels, F. Hardeman, I. Berkes, et al.. Level mixing resonances on oriented nuclei. International Symposium On Nuclear Orientation And Nuclei Far From Stability, Aug 1984, Leuven, Belgium. pp.131-149. ⟨in2p3-00013381⟩
  • J. Sau. A quasi particle approach to relaxation phenomena. International Symposium On Nuclear Orientation And Nuclei Far From Stability, Aug 1984, Leuven, Belgium. pp.125-130. ⟨in2p3-00013463⟩
  • I. Berkes, B. Hlimi, G. Marest, J. Sau, E.H. Sayouty. The magnetic moment of the 193-os(3/2-) ground state. International Symposium On Nuclear Orientation And Nuclei Far From Stability, Aug 1984, Leuven, Belgium. pp.591-596. ⟨in2p3-00013384⟩
  • I. Berkes. Magnetic moment measurement by nuclear orientation. International Symposium On Nuclear Orientation And Nuclei Far From Stability, Aug 1984, Leuven, Belgium. pp.547-557. ⟨in2p3-00004671⟩

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