Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • M. Giffon, R. Nahabetian, E. Predazzi. Multiparticle unitarity slopes and KNO scaling violation in NN and N anti-N. Conference on Elastic and Diffractive Scattering at the Collider and Beyond, Jun 1985, Blois, France. pp.15. ⟨in2p3-00019720⟩
    • Monique Rousset, M. Laburthe, M. Pinto, G. Chevalier, C. Rouyer-Fessard, et al.. Enterocytic differentiation and glucose utilization in the human colon tumor cell line Caco-2: modulation by forskolin.. Journal of Cellular Physiology, 1985, 123 ((3)), pp.377-85. ⟨10.1002/jcp.1041230313⟩. ⟨hal-00814012⟩
    • M. Ericson. Pionic effects in nuclei. Workshop On Perspectives In Nuclear Physics At Intermediate Energies 2, Mar 1985, Trieste, Italy. pp.204-227. ⟨in2p3-00004346⟩
    • B. M. Wice, G. Trugnan, M. Pinto, Monique Rousset, G. Chevalier, et al.. The intracellular accumulation of UDP-N-acetylhexosamines is concomitant with the inability of human colon cancer cells to differentiate.. Journal of Biological Chemistry, 1985, 260 ((1)), pp.139-46. ⟨hal-00814015⟩
    • A. Charvet, T. Ollivier, R. Béraud, R. Duffait, A. Emsallem, et al.. Identification and decay of ^{12} s ^{138}Eu. Zeitschrift für Physik. A, Atoms and Nuclei, 1985, 321, pp.697-698. ⟨10.1007/BF01432449⟩. ⟨in2p3-00005291⟩
    • J. Delorme, M. Ericson. Exploration of the spin-isospin nuclear response function by neutrinos. Physics Letters B, 1985, 156, pp.263-266. ⟨in2p3-00004314⟩
    • A. Huck, G. Klotz, A. Knipper, C. Miehe, C. Richard-Serre, et al.. Beta decay of the new isotopes ^{52}K ^{52}Ca and ^{52}Sc, a test of the shell model far from stability. Physical Review C, 1985, 31, pp.2226-2237. ⟨in2p3-00013425⟩
    • R. Bertini, J. Arvieux, M. Boivin, J.M. Durand, F. Soga, et al.. A strong energy dependence of the analyzing power in the pp\rightarrow d \pi^+ reaction and the question of an isovector dibaryon resonance. Physics Letters B, 1985, 162, pp.77-80. ⟨in2p3-00013406⟩
    • P.A.M. Guichon. Constraints and excited states of the bag. Physics Letters B, 1985, 163, pp.221-225. ⟨in2p3-00005486⟩
    • M. Giffon, E. Predazzi. Elastic slopes and diffraction. Physics Letters B, 1985, 150, pp.317-321. ⟨in2p3-00009687⟩

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