Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • N. Krah, L. de Marzi, A. Patriarca, G. Pitta, I. Rinaldi. Proton radiography with a commercial range telescope detector using dedicated post processing methods. Physics in Medicine and Biology, 2018, 63 (20), pp.205016. ⟨10.1088/1361-6560/aae043⟩. ⟨hal-01976834⟩
    • D. Pitoux, Z. Hu, B. Plainchont, D. Merlet, Jonathan Farjon, et al.. Combining pure shift and J -edited spectroscopies: A strategy for extracting chemical shifts and scalar couplings from highly crowded proton spectra of oligomeric saccharides. Magnetic Resonance in Chemistry, 2018, 56 (10), pp.954-962. ⟨10.1002/mrc.4715⟩. ⟨hal-02145857⟩
    • D. Davesne, J. Navarro, A. Pastore. Linear Response Theory for the Gogny Interaction. 25th Nuclear Physics Workshop 'Marie & Pierre Curie' on Essential Problems in Nuclear Physics, Sep 2018, Kazimierz Dolny, Poland. pp.549-556, ⟨10.5506/APhysPolBSupp.12.549⟩. ⟨hal-01937647⟩
    • P. Martinet, N. BĂ©rerd, B. Normand, N. Moncoffre, S. Joly-Marcelin, et al.. Tribocorrosion sous irradiation d’un acier inoxydable AISI 316L : Etude prĂ©liminaire. ConfĂ©rence IBAF (Ion Beam Analysis-Francophone), Sep 2018, Nouan le Fuzelier, France. ⟨in2p3-02096844⟩
    • L. Feketeová, T. Salbaing, F. Berthias, P. Bertier, H. Abdoul-Carime, et al.. Out of equilibrium dynamics of water nanodroplets. European Astrobiology Network Association (EANA 2018), Sep 2018, Berlin, Germany. ⟨in2p3-02098158⟩
    • Y. Pipon, Guillaume Victor, L. Sarrasin, N. Moncoffre, P.M. Gueye, et al.. Effets d’endommagement sur la migration du deutĂ©rium dans le carbure de bore. ConfĂ©rence IBAF (Ion Beam Analysis-Francophone), Sep 2018, Nouan le Fuzelier, France. ⟨in2p3-02096822⟩
    • Linda Feketeová. Out of equilibrium dynamics of water nanodroplets. European Astrobiology Network Association (EANA 2018), Sep 2018, Berlin, Germany. ⟨in2p3-02072383⟩
    • Alexandra Lauret, Pierre Philouze, CĂ©line MalĂ©sys, Philippe CĂ©ruse, Jonathan Lopez, et al.. Transcriptomic profile of HNSCC cancer : from the original site to the circulating tumoral cells. 2018 Radiation Research Society Annual Meeting, Sep 2018, Chicago, United States. ⟨hal-02051060⟩
    • Anne-Sophie Wozny, Gersende Alphonse, Guillaume Vares, Caterina Monini, Jean-Baptiste Guy, et al.. Spatial ROS distribution to explains the differences in the invasion/migration processes of cancer stem cells in response to photons and carbon ions. 64th Annual Meeting of the Radiation Research Society, Sep 2018, Chicago, United States. ⟨hal-02063655⟩
    • Alexandra Lauret, Pierre Philouze, CĂ©line MalĂ©sys, Jonathan Lopez, Philippe CĂ©ruse, et al.. Circulating tumor cells in the future of personalized radio(chimio)therapy for HNSCC patients. 64th Annual Meeting of the Radiation Research Society, Sep 2018, Chicago, United States. ⟨hal-02063575⟩

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