Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • L. Feketeová, T. Salbaing, F. Berthias, P. Bertier, H. Abdoul-Carime, et al.. Out of equilibrium dynamics of water nanodroplets. European Astrobiology Network Association (EANA 2018), Sep 2018, Berlin, Germany. ⟨in2p3-02098158⟩
  • Linda Feketeová. Out of equilibrium dynamics of water nanodroplets. European Astrobiology Network Association (EANA 2018), Sep 2018, Berlin, Germany. ⟨in2p3-02072383⟩
  • Anne-Sophie Wozny, Gersende Alphonse, Guillaume Vares, Caterina Monini, Jean-Baptiste Guy, et al.. Spatial ROS distribution to explains the differences in the invasion/migration processes of cancer stem cells in response to photons and carbon ions. 64th Annual Meeting of the Radiation Research Society, Sep 2018, Chicago, United States. ⟨hal-02063655⟩
  • Alexandra Lauret, Pierre Philouze, CĂ©line MalĂ©sys, Philippe CĂ©ruse, Jonathan Lopez, et al.. Transcriptomic profile of HNSCC cancer : from the original site to the circulating tumoral cells. 2018 Radiation Research Society Annual Meeting, Sep 2018, Chicago, United States. ⟨hal-02051060⟩
  • Alexandra Lauret, Pierre Philouze, CĂ©line MalĂ©sys, Jonathan Lopez, Philippe CĂ©ruse, et al.. Circulating tumor cells in the future of personalized radio(chimio)therapy for HNSCC patients. 64th Annual Meeting of the Radiation Research Society, Sep 2018, Chicago, United States. ⟨hal-02063575⟩
  • R. Meissner, C. Lochmann, L. Feketeová. Effectiveness of different isolated nitroimidazoles upon low energy electron interactions,. 7th Annual Center for Molecular Biosciences Innsbruck (CMBI) Meeting 2018, Sep 2018, Grillhof, Vill, Austria. ⟨in2p3-02098149⟩
  • Benedetta Nodari. A 65 nm Data Concentration ASIC for the CMS Outer Tracker Detector Upgrade at HL-LHC. Topical Workshop on Electronics for Particle Physics (TWEPP 2018), Sep 2018, Anvers, Belgium. ⟨hal-02053122⟩
  • Simone Scarfì, Alessandro Caratelli, Luigi Caponetto, Davide Ceresa, Geoffrey Galbit, et al.. A System-Verilog Verification Environment for the CIC Data Concentrator ASIC of the CMS Outer Tracker Phase-2 Upgrades. Topical Workshop on Electronics for Particle Physics, Sep 2018, Antwerpen, Belgium. pp.097, ⟨10.22323/1.343.0097⟩. ⟨hal-02283546⟩
  • Benedetta Nodari, Luigi Caponetto, Geoffrey Christian Galbit, Sebastien Viret, Simone Scarfi. A 65 nm Data Concentration ASIC for the CMS Outer Tracker Detector Upgrade at HL-LHC. Topical Workshop on Electronics for Particle Physics, Sep 2018, Antwerpen, Belgium. pp.099, ⟨10.22323/1.343.0099⟩. ⟨hal-02283547⟩
  • Xiushan Chen, Xueying Lin-Ma, Christophe Combaret, Laurent Mirabito, Guo-Neng Lu, et al.. Improved Tapped-Delay-Line Time-to-Digital Converter with Time-over-Threshold measurement for a new generation of Resistive Plate Chamber detectors. Topical Workshop on Electronics for Particle Physics, Sep 2018, Antwerpen, Belgium. pp.141, ⟨10.22323/1.343.0141⟩. ⟨hal-02283511⟩

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