Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Goyot, B. Ille, P. Lebrun, J.-P. Martin. Performances of a preamplifier-silicon photodiode readout system associated with large BGO crystal scintillators. Pisa Meeting On Advanced Detectors 3, Jun 1986, Castiglione Della Pescaia, Italy. pp.180-187. ⟨in2p3-00015281⟩
  • Houmani El Mamouni. Etude d'un prototype de calorimètre Ă©lectromagnĂ©tique Ă  cristaux de BGO pour l'expĂ©rience L3. Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I, 1986. Français. ⟨NNT : ⟩. ⟨tel-00746626⟩
  • Abderrahim Ziani. Application de techniques de diffusion elastique de particules alpha et d'ions lourds a l'analyse chimique des couches minces et des surfaces. Physique des accĂ©lĂ©rateurs [physics.acc-ph]. UniversitĂ© Claude Bernard - Lyon I, 1986. Français. ⟨NNT : ⟩. ⟨tel-00744146⟩
  • J. Fay. Formation des etats \chi_1 et \chi_2 du charmonium dans l'annihilation p\bar{p} aux ISR. Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I, 1986. Français. ⟨NNT : ⟩. ⟨tel-00744515⟩
  • Patrice Lebrun. Contribution Ă  l'Ă©tude du calorimètre Ă©lectromagnĂ©tique Ă  cristaux de germanate de bismuth de l'expĂ©rience L3 sur LEP. Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I, 1986. Français. ⟨NNT : ⟩. ⟨tel-00747138⟩
  • R. Duffait, A. Charvet, K. Deneffe, R. BĂ©raud, A. Emsallem, et al.. High-spin states in odd-odd ^{100,102,104}Rh. Nuclear Physics A, 1986, 454, pp.143-162. ⟨10.1016/0375-9474(86)90152-1⟩. ⟨in2p3-00004090⟩
  • W.M. Alberico, A. Molinari, A. de Pace, M. Ericson, M.B. Johnson. Random phase approximation spin-isospin nuclear response in the deep inelastic region. Physical Review C, 1986, 34, pp.977-990. ⟨10.1103/PhysRevC.34.977⟩. ⟨in2p3-00004319⟩
  • M. Ericson, M. Rosa-Clot. The electromagnetic polarizability and the swelling of nucleons in the nucleus. Zeitschrift fĂĽr Physik. A, Atoms and Nuclei, 1986, 324, pp.373-379. ⟨in2p3-00004321⟩
  • R. Kossakowski, S. Andre, J. Genevey, A. Gizon, V. Barci, et al.. Incomplete mass transfer in ^{12}C and ^{14}N reactions on medium-heavy targets at 15 and 30 MeV/nucleon. Physical Review C, 1986, 33, pp.1514-1516. ⟨10.1103/PhysRevC.33.1514⟩. ⟨in2p3-00013482⟩
  • E. Pollacco, J. Alarja, Y. Cassagnou, B. Chambon, B. Cheynis, et al.. EVOLUTION OF THE FUSION LIKE PROCESS AROUND THE FERMI ENERGY. International Conference on Heavy Ion Nuclear Collisions in the Fermi Energy Domain, 1986, Caen, France. pp.C4-377-C4-380, ⟨10.1051/jphyscol:1986443⟩. ⟨jpa-00225809⟩

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