Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • I. Berkes, O. El Hajjaji, M. Fahad, G. Marest. Low temperature nuclear orientation of ^{149,151}Gd in gadolinium. International Conference On Hyperfine Interactions And Exhibition 7, Sep 1986, Bangalore, India. pp.119-122. ⟨in2p3-00004527⟩
  • G. Langouche, M. van Der Heyden, M. Tong, I. Berkes, M. Fahad, et al.. Local nuclear orientation using defect-induced electric field gradients in cubic lattices. International Conference On Hyperfine Interactions And Exhibition 7, Sep 1986, Bangalore, India. pp.1027-1031. ⟨in2p3-00004526⟩
  • G. Marest, N. Kornilios, A. Perez, F. Ravel, P. Gerard, et al.. Morin transition in annealed iron implanted garnets. International Conference On Hyperfine Interactions And Exhibition 7, Sep 1986, Bangalore, India. pp.943-946. ⟨in2p3-00004528⟩
  • N. Redon, J. Meyer, M. Meyer, P. Quentin, M.S. Weiss, et al.. A Self-Consistent Study of Triaxial Deformations in Heavy Nuclei. International Nuclear Physics Conference 86, Aug 1986, Harrogate, United Kingdom. pp.75. ⟨in2p3-00010072⟩
  • K. Bencheikh, P. Quentin, M. Brack, J. Libert, J. Meyer, et al.. A simple microscopic approach of deformation energy surfaces for axial and non axial quadrupole variables. International Nuclear Physics Conference, Aug 1986, Harrogate, United Kingdom. pp.74. ⟨in2p3-00014592⟩
  • D.E. Medjadi, P. Quentin, M. Meyer, J. Libert. Coupling of one quasiparticle to the general solution of a Bohr collective hamiltonian and the description of odd-even nuclei. International Nuclear Physics Conference, Aug 1986, Harrogate, United Kingdom. pp.72. ⟨in2p3-00014593⟩
  • A. Plantier, R. Béraud, T. Ollivier, A. Charvet, R. Duffait, et al.. Connection of a He-jet to the medium-current source of the SARA on-line separator. International Conference On Electromagnetic Isotope Separators And Techniques Related To Their Applications 11, Aug 1986, Los Alamos, United States. pp.314-320. ⟨in2p3-00004104⟩
  • N. Moncoffre. Nitrogen implantation into steels. International Conference On Surface Modification Of Metals By Ion Beams 5, Jul 1986, Kingston, Canada. pp.99-109. ⟨in2p3-00013437⟩
  • G. Chanfray. Semi-classical calculation of the nuclear spin-isospin response functions.. International Symposium On Weak And Electromagnetic Interactions In Nuclei And Exhibition, Jul 1986, Heidelberg, Germany. pp.431-434. ⟨in2p3-00004681⟩
  • M. Ericson. The EMC effect and the swelling of nucleons in nuclei.. International Symposium On Weak And Electromagnetic Interactions In Nuclei And Exhibition, Jul 1986, Heidelberg, Germany. pp.382-392. ⟨in2p3-00004351⟩

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