Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • A. Gavron, A. Gayer, J. Boissevain, H.C. Britt, J-R. Beene, et al.. Neutron emission in the fissioning ^{158}Er composite system. Physical Review C, 1987, 35, pp.579-590. ⟨in2p3-00014848⟩
  • J. Delorme, I.S. Towner. Relativistic shell models and meson-exchange currents. Nuclear Physics A, 1987, 475, pp.720-742. ⟨in2p3-00002220⟩
  • G. Chanfray. Calculation of the spin-isospin response functions in an extended semi-classical theory. Nuclear Physics A, 1987, 474, pp.114-130. ⟨in2p3-00000426⟩
  • J. Tousset. Nuclear surface analysis techniques in the field of surface treatments. Traitement Thermique, 1987, 21, pp.13-15. ⟨in2p3-00004677⟩
  • B. Farizon, A. Belkacem, M. Chevallier, M.J. Gaillard, J.-C. Poizat, et al.. Foil dissociation of 40-120 KeV/p hydrogen cluters. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1987, 28, pp.497-501. ⟨in2p3-00013304⟩
  • N. Bensayah, J. Berthot, P.Y. Bertin, A. Devaux, H. Fonvieille, et al.. Electroproduction of \pi^+ at threshold on the nucleon. Workshop on Photo Production and Electroproduction of Mesons on the Nucleon and Nuclei, Nov 1986, Clermont-Ferrand, France. pp.17. ⟨in2p3-00019745⟩
  • M. Giffon. Les journees de Lyon : une tentative pour un bilan. Workshop on Photo-Production and Electroproduction of Mesons on the Nucleon and Nuclei, Nov 1986, Clermont-Ferrand, France. ⟨in2p3-00011033⟩
  • D. Lambert, M. Kibler. Levi-Civita Kustaanheimo-Stiefel and other transformations. International Colloquium on Group Theoretical Methods in Physics 15, Oct 1986, Drexel, United States. pp.475-485. ⟨in2p3-00003738⟩
  • P.A.M. Guichon. Symétrie chirale. École thématique. Ecole Joliot Curie "Symétries et physique nucléaire", Maubuisson, (France), du 15-19 septembre 1986 : 5ème session, 1986. ⟨cel-00644028⟩
  • I. Berkes, O. El Hajjaji, M. Fahad, B. Hlimi, G. Marest, et al.. Nuclear moment determination by Moessbauer effect detection of low temperature nuclear orientation (no/me). International Conference On Hyperfine Interactions And Exhibition. 7, Sep 1986, Bangalore, India. pp.1023-1026. ⟨in2p3-00015208⟩

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