Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8768 documents

    • T. Mizutani, B. Saghai, C. Fayard, G.-H. Lamot. Effect of \pi d channel coupling on the medium energy nucleon-nucleon interaction. Physical Review C, 1987, 35, pp.667-674. ⟨in2p3-00022955⟩
    • C. Baglin, G. Bassompierre, J.C. Brient, C. Broll, A. Bussiere, et al.. Direct observation and partial-width measurement of \gamma \gamma decay of charmonium states. Physics Letters B, 1987, 187, pp.191-197. ⟨in2p3-00013392⟩
    • J.L. Charvet, G. Duchene, S. Joly, C. Magnago, M. Morjean, et al.. Binary break-up of a high-velocity hot source formed in the ^{84}Kr + ^{93}Nb reaction at 34.5 MeV/u. Physics Letters B, 1987, 199, pp.388-392. ⟨in2p3-00013340⟩
    • S. Andriamonje, M. Chevallier, C. Cohen, J. Dural, M.J. Gaillard, et al.. Observation of radiation electron capture into KLM shells of 25 MeV/u Xe^{53+} ions channeled in silicon. Physical Review Letters, 1987, 59, pp.2271-2274. ⟨in2p3-00003102⟩
    • J. Delorme, I.S. Towner. Relativistic shell models and meson-exchange currents. Nuclear Physics A, 1987, 475, pp.720-742. ⟨in2p3-00002220⟩
    • A. Gavron, A. Gayer, J. Boissevain, H.C. Britt, J-R. Beene, et al.. Neutron emission in the fissioning ^{158}Er composite system. Physical Review C, 1987, 35, pp.579-590. ⟨in2p3-00014848⟩
    • G. Chanfray. Calculation of the spin-isospin response functions in an extended semi-classical theory. Nuclear Physics A, 1987, 474, pp.114-130. ⟨in2p3-00000426⟩
    • M. Giffon. Les journees de Lyon : une tentative pour un bilan. Workshop on Photo-Production and Electroproduction of Mesons on the Nucleon and Nuclei, Nov 1986, Clermont-Ferrand, France. ⟨in2p3-00011033⟩
    • N. Bensayah, J. Berthot, P.Y. Bertin, A. Devaux, H. Fonvieille, et al.. Electroproduction of \pi^+ at threshold on the nucleon. Workshop on Photo Production and Electroproduction of Mesons on the Nucleon and Nuclei, Nov 1986, Clermont-Ferrand, France. pp.17. ⟨in2p3-00019745⟩
    • D. Lambert, M. Kibler. Levi-Civita Kustaanheimo-Stiefel and other transformations. International Colloquium on Group Theoretical Methods in Physics 15, Oct 1986, Drexel, United States. pp.475-485. ⟨in2p3-00003738⟩

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