Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • W.M. Alberico, P. Czerski, A. Molinari, M. Ericson. Inclusive charge longitudinal response in finite nuclei. Nuclear Physics A, 1987, 462, pp.269-289. ⟨in2p3-00004252⟩
  • C. Baglin, G. Bassompierre, J.C. Brient, C. Broll, A. Bussiere, et al.. J/ \psi resonant formation and mass measurement in antiproton-proton annihilations. Nuclear Physics B, 1987, 286, pp.592-634. ⟨in2p3-00013394⟩
  • M. Stern-Jacquin. Collisions peripheriques induites par des ions lourds. - Fragmentation du projectile ^{20}Ne a 30 MeV/nucleon retrodiffusion a 0.5 MeV-nucleon. - Methode d'analyse de surface. Nuclear Experiment [nucl-ex]. Université Claude Bernard - Lyon I, 1987. English. ⟨NNT : ⟩. ⟨in2p3-00013441⟩
  • M. Giffon, R. Nahabetian, E. Predazzi. Unitarity asymptotic constraints and hadronic slopes. Zeitschrift für Physik. C, Particles and Fields, 1987, 36, pp.67-75. ⟨in2p3-00015049⟩
  • M. Ericson, M. Rosa-Clot. Compton scattering and pion number in nuclei. Physics Letters B, 1987, 188, pp.11-16. ⟨in2p3-00004251⟩
  • J. Meyer, Y. Zhu. Second harmonic emission from an underdense laser-produced plasma and filamentation. Physics of Fluids, 1987, 30, pp.890-895. ⟨in2p3-00004560⟩
  • M. Bedjidian, D. Contardo, E. Descroix, S. Gardien, J.-Y. Grossiord, et al.. A detection system using drift chambers for the SPES4 spectrometer at Laboratoire National Saturne. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1987, 257, pp.132-138. ⟨in2p3-00004127⟩
  • I. Bergqvist, A. Brockstedt, L. Carlen, L.P. Ekstroem, B. Jakobsson, et al.. The (^3He,t) reaction at intermediate energies: spin-isospin transitions to states in ^{12}N and ^{13}N. Nuclear Physics A, 1987, 469, pp.648-668. ⟨10.1016/0375-9474(87)90019-4⟩. ⟨in2p3-00005295⟩
  • M. Bedjidian, D. Contardo, E. Descroix, S. Gardien, J.-Y. Grossiord, et al.. Search for a nucleon-participant multiplicity effect on a possible anomalous fragment production. Zeitschrift für Physik. A, Atoms and Nuclei, 1987, 327, pp.337-340. ⟨10.1007/BF01284458⟩. ⟨in2p3-00004128⟩
  • A. Figureau. Information theory and the genetic code. Origins of Life and Evolution of the Biosphere, 1987, 17, pp.439-448. ⟨in2p3-00022870⟩

Powered by HAL logo