Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J.A. Sawicki, G. Marest, B. Cox, S.R. Julian. Moessbauer spectroscopy of iron implanted and doped in ZrO_2. International Conference On Radiation Effects In Insulators - Including,Workshop On Radiation Damage In Nuclear Waste Materials 4, Jul 1987, Lyon, France. pp.79-84. ⟨in2p3-00004659⟩
  • J. Libert, L. Bennour, D. Medjadi, M. Meyer, P. Quentin, et al.. Single particle and collective degrees of freedom in heavy deformed nuclei: a microscopic description. International Conference on Nuclear Shapes, Jun 1987, Aghia Pelaghai, Greece. pp.21-35. ⟨in2p3-00014484⟩
  • M. Kibler. Application of non-bijective transformations to various potentials. International Colloquium on Group Theoretical Methods in Physics 16, Jun 1987, Varna, Bulgaria. pp.238-244. ⟨in2p3-00008101⟩
  • N. Moncoffre, H. Jaffrezic, G. Marest, J. Tousset, F.C. Zawislak, et al.. Compared nitrogen implantations of various alloyed steels. Materials Research Society Spring Meeting, Apr 1987, Anaheim, United States. pp.341-348. ⟨in2p3-00013273⟩
  • M. Ericson. The electromagnetic properties of the nucleon in the nucleus and emc effect. Yukawa International Seminar : Mesons And Quarks In Nuclei 1, Apr 1987, Kyoto, Japan. pp.235-243. ⟨in2p3-00004343⟩
  • D. Drain, A. Giorni, H. Nifenecker, F. Merchez, J.F. Cavaignac, et al.. Applications of pulse shape discrimination with scintillators. 4 \pi detector small \delta p detector array large neutron detector. National Meeting Of The American Chemical Society 193, Apr 1987, Denver, United States. pp.PM. ⟨in2p3-00004074⟩
  • D. Fabris, K. Hagel, J.B. Natowitz, G. Nebbia, R. Wada, et al.. Limiting temperatures of medium mass nuclei. Symposium On Central Collisions And Fragmentation Processes,National Meeting Of The American Chemical Society.193, Apr 1987, Denver, United States. pp.351C-353C. ⟨in2p3-00014846⟩
  • E.M. Eckert, K.D. Hildenbrand, U. Lynen, W.F.J. Mueller, H.J. Rabe, et al.. Reaction mechanisms of ^{40}Ar induced peripheral collisions at 30 MeV/u. Dpg Spring Meeting Of The Nuclear Physics Sections, Mar 1987, Groningen, Netherlands. pp.6-7. ⟨in2p3-00013352⟩
  • N. Bensayah, J. Berthot, P.Y. Bertin, A. Devaux, H. Fonvieille, et al.. Electroproduction of \pi^+ at threshold on the nucleon. Session d'Etudes Biennale de Physique Nucleaire 9, Mar 1987, Aussois, France. ⟨in2p3-00019724⟩
  • L. Bennour, J. Libert, D. Medjadi, M. Meyer, P. Quentin. A microscopic description of low energy excitations of even, odd and odd-odd nuclei. Session d'Etudes Biennale de Physique Nucleaire 9, Mar 1987, Aussois, France. pp.S9-1-S9-13. ⟨in2p3-00014595⟩

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