Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • B. Farizon, A. Belkacem, M. Chevallier, M.J. Gaillard, J.-C. Poizat, et al.. Charge exchange processes of foil dissociation fragments of fast H^2 ions and H^+ clusters. International Conference On Atomic Collisions In Solids 12, Oct 1987, Okayama, Japan. pp.105-107. ⟨in2p3-00007645⟩
  • E. Predazzi, M. Giffon, R. Nahabetian. Hadronic slopes and unitarity. International Conference on Elastic and Diffractive Scattering 2, Oct 1987, New York, United States. ⟨in2p3-00019723⟩
  • R. Béraud, A. Charvet, R. Duffait, A. Emsallem, J. Genevey, et al.. Identification and structure of p-rich rare-earth nuclei investigated using a He-jet fed on-line mass-separator. International Conference On Nuclei Far From Stability 5, Sep 1987, Lake Rosseau, Canada. pp.445-454. ⟨in2p3-00004683⟩
  • J. Genevey, A. Gizon, N. Idrissi, B. Weiss, R. Béraud, et al.. Decay of new mass-separated neutron-deficient La and Ce isotopes. International Conference on Nuclei Far From Stability 5, Sep 1987, Lake Rosseau, Canada. pp.419-424. ⟨in2p3-00022760⟩
  • D. Schardt, R. Barden, R. Kirchner, O. Klepper, A. Plochocki, et al.. Q-values and isomer energies from high-resolution alpha-, proton-, and gamma-ray spectroscopy above ^{146}Gd. International Conference on Nuclei Far from Stability 5, Sep 1987, Rosseau Lake Ontario, Canada. pp.477-488. ⟨in2p3-00013194⟩
  • P. Quentin, L. Bennour, J. Libert, M.G. Porquet, D.E. Medjadi, et al.. Low-energy coupling of individual and collective degrees of freedom: a general microscopic approach. International Symposium on Capture Gamma-Ray Spectroscopy 6, Aug 1987, Leuven, Belgium. pp.S47-S54. ⟨in2p3-00013163⟩
  • C. Fayard, G.-H. Lamot, T. Mizutani, B. Saghai. Nn \rightarrow n \delta process in the \pi nn theory. European Conference On Few-Body Physics 11, Aug 1987, Fontevraud, France. pp.453-458. ⟨in2p3-00022936⟩
  • A. Bussiere, C. Baglin, J.P. Guillaud, M.C. Abreu, G.P. Barreira, et al.. The production of j/\psi in 200 GeV/A oxygen-uranium interactions. International Conference On Ultra-Relativistic Nucleus-Nucleus Collisions - Quark Matter '87 6, Aug 1987, Nordkirchen, Germany. pp.117-124. ⟨in2p3-00004126⟩
  • P. Sonderegger, M.C. Abreu, G.P. Barreira, P. Bordalo, A. Casaca, et al.. A study of pi and K production in proton-uranium and oxygen-uranium interactions of 200 GeV/A using decay muons. International Conference On Ultra-Relativistic Nucleus-Nucleus Collisions.6, Quark Matter '87, Aug 1987, Nordkirchen, Germany. pp.129-133. ⟨in2p3-00001086⟩
  • J.-P. Thomas, A. Oladipo, M. Fallavier. Desorption induced by H_{n+} clusters (7 = n = 61) at 600 KeV. International Conference On Radiation Effects In Insulators On Radiation Damage In Nuclear Waste Materials 4, Jul 1987, Lyon, France. pp.354-359. ⟨in2p3-00007647⟩

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