Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • L. Sarrasin, C. Pannetier, Clotilde Gaillard, Y Pipon, N Moncoffre, et al.. Effect of the oxygen partial pressure on the migration of molybdenum in UO_2. Numat 2018, Oct 2018, Seattle, United States. ⟨in2p3-02095560⟩
    • Caterina Monini, Etienne Testa, Michael Beuve. NanOx model: how to predict RBE for hadrontherapy. International Marie Sklodowska-Curie Meeting: from Radiation to Innovation in Medicine 2018, Oct 2018, Paris, France. ⟨hal-02050642⟩
    • Stephan Denifl, R. Meissner, J. Ameixa, E. Arthur-Baidoo, C. Lochmann, et al.. Low-energy electron scattering from radiosensitizers: Associative vs. dissociative attachment. International Conference "Dynamics of Systems on the Nanoscale" DySoN 2018, Oct 2018, Potsdam, Germany. ⟨in2p3-02098167⟩
    • Nicolas Baillot d'Étivaux. Équation d’état de la matière Ă  densitĂ© supranuclĂ©aire et application Ă  l’émission thermique des Ă©toiles compactes. Astrophysique [astro-ph]. UniversitĂ© de Lyon, 2018. Français. ⟨NNT : 2018LYSE1168⟩. ⟨tel-02002295⟩
    • Nodoka Yamanaka, C. Hadjidakis, D. KikoĹ‚a, J.P. Lansberg, L. Massacrier, et al.. Ultra-peripheral-collision studies in the fixed-target mode with the proton and lead LHC beams. 9th International Conference on Hard and Electromagnetic Probes of High-Energy Nuclear Collisions, Oct 2018, Aix-Les-Bains, France. pp.184, ⟨10.22323/1.345.0184⟩. ⟨hal-02058535⟩
    • G. Vogin, A. Wambersie, R. Pötter, M. Beuve, S.E. Combs, et al.. Concepts and terms for dose/volume parameters in carbon-ion radiotherapy: Conclusions of the ULICE taskforce. Cancer/RadiothĂ©rapie, 2018, 22 (8), pp.802-809. ⟨10.1016/j.canrad.2017.11.016⟩. ⟨hal-01909661⟩
    • A.M. Sirunyan, A. Tumasyan, W. Adam, F. Ambrogi, E. Asilar, et al.. Precision measurement of the structure of the CMS inner tracking system using nuclear interactions. Journal of Instrumentation, 2018, 13 (10), pp.P10034. ⟨10.1088/1748-0221/13/10/P10034⟩. ⟨hal-03670328⟩
    • Antonio Uras. Heavy-flavour-production studies in a new energy and rapidity domain with AFTER@LHC. 9th International Conference on Hard and Electromagnetic Probes of High-Energy Nuclear Collisions : Hard Probes 2018. (HP2018), Oct 2018, Aix-les-Bains, France. ⟨hal-02082243⟩
    • N. Krah, L. de Marzi, A. Patriarca, G. Pitta, I. Rinaldi. Proton radiography with a commercial range telescope detector using dedicated post processing methods. Physics in Medicine and Biology, 2018, 63 (20), pp.205016. ⟨10.1088/1361-6560/aae043⟩. ⟨hal-01976834⟩
    • D. Pitoux, Z. Hu, B. Plainchont, D. Merlet, Jonathan Farjon, et al.. Combining pure shift and J -edited spectroscopies: A strategy for extracting chemical shifts and scalar couplings from highly crowded proton spectra of oligomeric saccharides. Magnetic Resonance in Chemistry, 2018, 56 (10), pp.954-962. ⟨10.1002/mrc.4715⟩. ⟨hal-02145857⟩

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