Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • N. Redon, J. Meyer, M. Meyer, P. Quentin, P. Bonche, et al.. Proton-rich exotic heavy nuclei: self-consistent calculations. Physical Review C, 1988, 38, pp.550-552. ⟨in2p3-00002876⟩
  • M. Kibler, P. Winternitz. Lie algebras under constraints and non-bijective canonical transformations. Journal of Physics A: Mathematical and Theoretical, 1988, 21, pp.1787-1803. ⟨in2p3-00002873⟩
  • G. Hadinger, Y.S. Tergiman. Further contributions to the energy levels of a perturbed anharmonic oscillator:application to adiabatic corrections. The Journal of Chemical Physics, 1988, 88, pp.4351-4356. ⟨in2p3-00014735⟩
  • G. Marest. Analysis of ion implanted ceramics studies of iron implanted MGO and Al2O3. Surface and Interface Analysis, 1988, 12, pp.509-518. ⟨in2p3-00013266⟩
  • M. Gouanere, D. Sillou, M. Spighel, N. Cue, M.J. Gaillard, et al.. Planar channeling radiation from 54-220 MeV electrons in diamond and silicon. Physical Review B: Condensed Matter and Materials Physics (1998-2015), 1988, 38, pp.4352-4371. ⟨in2p3-00002875⟩
  • M. Chevallier, N.V. de Castro Faria, B. Farizon-Mazuy, M. Gaillard, J.-C. Poizat, et al.. INTERACTION OF FAST HYDROGEN IONIC CLUSTERS WITH MATTER. International Workshop On Mev And Kev Ions And Cluster Interactions With Surfaces And Materials 2, 1988, Orsay, France. pp.C2-189-C2-193, ⟨10.1051/jphyscol:1989232⟩. ⟨jpa-00229430⟩
  • A. Belkacem, G. Bologna, M. Chevallier, N. Cue, M.J. Gaillard, et al.. Planar effects in 150 GeV positron radiation of a thin germanium crystal. EPL - Europhysics Letters, 1988, 5, pp.589-594. ⟨in2p3-00002877⟩
  • B. Farizon, A. Belkacem, M. Chevallier, A. Clouvas, M.J. Gaillard, et al.. Projectile velocity dependance of the 2p and 4p components in fast He^+ beams at emergence fron a carbon foil. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1988, 31, pp.382-385. ⟨in2p3-00002879⟩
  • Y. Jugnet, N.S. Prakash, L. Porte, Duc Tran Minh, T.T.A. Nguyen, et al.. Photoelectron diffraction on clean W(110) surface and bulk 4f core levels. Physical Review B: Condensed Matter and Materials Physics (1998-2015), 1988, 37, pp.8066-8071. ⟨in2p3-00015336⟩
  • R. Bertini, G. Roy, J.M. Durand, J. Arvieux, M. Boivin, et al.. Strong energy dependence of the analysing power in the pp \to d\pi^+ reaction and the question of an isovector dibaryon resonance.II. Physics Letters B, 1988, 203, pp.18-21. ⟨10.1016/0370-2693(88)91561-4⟩. ⟨in2p3-00004125⟩

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