Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J.-Y. Grossiord, M C. Abreu, M. Alimi, C. Baglin, A. Baldit, et al.. Dimuon production in collisions of proton oxygen and sulfur ions on heavy targets at 200 GeV/nucleon J/\psi production \pi and K distributions. International Conference on Ultra-relativistic Nucleus-nucleus Collisions 7, Sep 1988, Lenox, United States. pp.249C-260C, ⟨10.1016/0375-9474(89)90603-9⟩. ⟨in2p3-00005152⟩
  • R. Frascaria, R. Siebert, J.P. Didelez, G. Blanpied, T. Reposeur, et al.. Hyperon-nucleon final-state interaction in a pp \rightarrow K^+ X experiment and the H^+_l(2130) S=-1 strange dibaryon. International Symposium on Hypernuclear and Low-Energy Kaon Physics, Sep 1988, Legnaro, Italy. pp.561-573. ⟨in2p3-00016394⟩
  • M. Kibler, P. Labastie. Transformations generalizing the Levi-Civita Kustaanheimo-Stiefel and fock transformations. International Colloquium on Group Theoretical Methods in Physics 17, Jun 1988, Sainte Adele, Canada. pp.660-671. ⟨in2p3-00003236⟩
  • G. Chanfray, Jean-Francois Mathiot, H.J. Pirner. Color dielectric approach to the nucleon and nuclear matter. European Workshop on Hadronic Physics in the 1990'S with Multi-GeV Electrons 1, Jun 1988, Seillac, France. pp.247C-252C. ⟨in2p3-00005304⟩
  • J. Meyer, M. Meyer, N. Redon, P. Quentin, P. Bonche, et al.. Self-consistent calculations of iron isotopes near the neutron drip line. International Conference on Nucleus Nucleus Collisions 3, Jun 1988, Saint-Malo, France. pp.17. ⟨in2p3-00004119⟩
  • P. Schuck, W. Noerenberg, G. Chanfray. Two pion cooper pair in nuclei ?. Spring Meeting Of Nuclear Physics Sections, Mar 1988, Berlin, Germany. pp.53. ⟨in2p3-00004395⟩
  • P. Kleinheinz, B. Rubio, J. Styczen, H. Gueven, J.L. Tain, et al.. Beta-decay of 27/2- high-spin isomers in N=83 nuclei. Spring Meeting Of The Fachausschuss Kern- Und Mittelenergiephysik Of The Deutsche Physikalische Gesellschaft E.V., Mar 1988, Berlin, Germany. pp.G5.5. ⟨in2p3-00013430⟩
  • P.F. Box, P. Decowski, K.A. Griffioen, R. Kamermans, R.J. Meijer, et al.. Evolution of the ^{28}Si + ^{(nat)}Si reaction mechanisms in the energy range 8-30 MeV/nucleon. Spring Meeting Of Nuclear Physics Sections, Mar 1988, Berlin, Germany. pp.120. ⟨in2p3-00013353⟩
  • P. Schuck, W. Norenberg, G. Chanfray. Bound two-pion cooper pairs in nuclei ?. International Workshop On Gross Properties Of Nuclei And Nuclear Excitations 16, Jan 1988, Hirschegg, Austria. pp.292-297. ⟨in2p3-00004241⟩
  • F. Gieres. Geometric approach to the BRS differential algebras of supersymmetric YM theories. Classical and Quantum Gravity, 1988, 5, pp.L27-L34. ⟨in2p3-00002484⟩

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