Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • L. Porte, M. Phaner, C.H. de Villeneuve, N. Moncoffre, J. Tousset. Scanning tunneling microscopy study of single-ion impacts on graphite surface. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1989, 44 (1), pp.116-119. ⟨10.1016/0168-583X(89)90696-4⟩. ⟨hal-02071451⟩
  • C. Baglin, A. Bussiere, J.P. Guillaud, H. Ogren, F. Staley, et al.. The production of j/\psi in 200 GeV/nucleon oxygen-uranium interactions. Physics Letters B, 1989, 220, pp.471-478. ⟨10.1016/0370-2693(89)90905-2⟩. ⟨in2p3-00003665⟩
  • D. Drain, A. Giorni, D. Hilscher, C. Ristori, J. Alarja, et al.. The particle detector array Amphora. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1989, 281, pp.528-538. ⟨10.1016/0168-9002(89)91487-3⟩. ⟨in2p3-00013341⟩
  • E. Voutier. Approche semiclassique de la self-energie du delta dans un noyau. - Application au probleme des fonctions reponses de spin-isospin. Nuclear Experiment [nucl-ex]. Université Claude Bernard - Lyon I, 1989. English. ⟨NNT : ⟩. ⟨in2p3-00015153⟩
  • C. Baglin, S. Baird, G. Bassompierre, C. Biino, G. Borreani, et al.. Precision measurements of the antiproton-proton elastic scattering cross section at 90 degrees in the incident momentum range between 3.5 GeV/c and 5.7 GeV/c. Physics Letters B, 1989, 225, pp.296-300. ⟨in2p3-00018891⟩
  • Jean-Francois Mathiot, G. Chanfray, H.J. Pirner. Phenomenology of color dielectrics in Su(3)color. Nuclear Physics A, 1989, 500, pp.605-626. ⟨in2p3-00004228⟩
  • F. Gieres. BRS invariant gauge fixing of local and global zero modes in superstring theory. Physics Letters B, 1989, 216, pp.87-93. ⟨in2p3-00002487⟩
  • Michel Farizon. Agrégats d'hydrogène - Structure et interaction avec des cibles solides. Agrégats Moléculaires et Atomiques [physics.atm-clus]. Université Claude Bernard - Lyon I, 1988. Français. ⟨NNT : ⟩. ⟨tel-00795192⟩
  • P. Schuck, G. Chanfray, W. Noerenberg. Is the sigma-field in the omega-sigma model related to a pion pair coherent state ?. International Workshop On Nuclear Dynamics At Medium And High Energies, Oct 1988, Bad Honnef, Germany. pp.355-362. ⟨in2p3-00004227⟩
  • A. Devaux, M.C. Abreu, M. Alimi, C. Baglin, A. Baldit, et al.. Calorimeter data from NA38. International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions. 7, Sep 1988, Lenox, United States. pp.509C-514C. ⟨in2p3-00005013⟩

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