Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Kibler, J.C. Gacon. Energy levels of paramagnetic ions algebra VI transition intensity calculations. Croatica Chemica Acta, 1989, 62, pp.783-797. ⟨in2p3-00002206⟩
  • H. Fonvieille, N. Bensayah, J. Berthot, P.Y. Bertin, B. Bihoreau, et al.. Dalitz decay \pi^0 \rightarrow \gamma e^+e^- and the \pi^0 electromagnetic transition form factor. Physics Letters B, 1989, 233, pp.65-68. ⟨in2p3-00004039⟩
  • F. Delduc, F. Gieres, S.P. Sorella. Supersymmetry of the d=3 Chern-Simons action in the Landau gauge. Physics Letters B, 1989, 225, pp.367-371. ⟨in2p3-00002488⟩
  • S.J. Gates, F. Gieres. Unidexterous supergravity Beltrami parametrization and BRST quantization. Nuclear Physics B, 1989, 320, pp.310-345. ⟨in2p3-00002486⟩
  • Y. Tahri. Contribution a l'etude theorique par la methode Ms-X alpha de composes susceptibles de se former sur inp. Université Claude Bernard - Lyon I, 1989. English. ⟨NNT : ⟩. ⟨in2p3-00013369⟩
  • A. Figureau. The genetic code and optimization. Origins of Life and Evolution of the Biosphere, 1989, 19, pp.57-67. ⟨in2p3-00022871⟩
  • H. Fonvieille, N. Bensayah, J. Berthot, P.Y. Bertin, B. Bihoreau, et al.. Inverse pion electroproduction at threshold \pi^-p \rightarrow Ne^+e^-. Physics Letters B, 1989, 233, pp.60-64. ⟨in2p3-00009695⟩
  • C. Ellegaard, C. Gaarde, T.S. Jorgensen, J.S. Larsen, B. Million, et al.. Spin structure of the \Delta excitation. Physics Letters B, 1989, 231, pp.365-369. ⟨in2p3-00013409⟩
  • J.-M. Augem. Etalonnage de la spectrometrie a decharge luminescente. - Application a l'analyse du cobalt dans l'acier 316 oxyde - Realisation d'etalons par implantation ionique. Conservatoire national des arts et metiers - CNAM, 1989. English. ⟨NNT : ⟩. ⟨in2p3-00013370⟩
  • C.H. Villeneuve, M. Phaner, P. Pertosa, L. Porte. Microscope par effet tunnel à l'air et en milieu liquide. Journal de Chimie Physique et de Physico-Chimie Biologique, 1989, 86, pp.1237-1244. ⟨10.1051/jcp/19898601237⟩. ⟨hal-02071492⟩

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