Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M.A. El Khakani, H. Jaffrezic, G. Marest, N. Moncoffre, J. Tousset. Sputtering yield and residual vacuum influence during titanium implantation into iron. European Conference On Accelerators In Applied Research And Technology 1, Sep 1989, Frankfurt, Germany. pp.406-409. ⟨in2p3-00014647⟩
  • H. Binczycka, G. Marest, N. Moncoffre, J. Stanek. Local states of iron in iron implanted hematite Fe2O3. International Conference On The Application Of The Mossbauer Effect, Sep 1989, Budapest, Hungary. pp.1557-1562. ⟨in2p3-00013254⟩
  • G. Marest, C. Donnet, N. Moncoffre, J. Tousset. Thermal evolution of high dose iron implanted sintered alumina. International Conference On The Application Of The Mossbauer Effect, Sep 1989, Budapest, Hungary. pp.1613-1620. ⟨in2p3-00013264⟩
  • A. L'Hoir, S. Andriamonje, R. Anne, N.V. de Castro Faria, M. Chevallier, et al.. Impact parameter dependence of energy loss and target-electron-induced ionization for 27 MeV/u Xe35+ incident ions transmitted in [110] Si channels. 13th International Conference on Atomic Collisions in Solids, Aug 1989, Aarhus, Denmark. pp.145-155, ⟨10.1016/0168-583X(90)90093-A⟩. ⟨in2p3-00719958⟩
  • A. L'Hoir, S. Andriamonje, R. Anne, N.V. de Castro Faria, M. Chevallier, et al.. Impact parameter dependence of energy loss and target electron induced ionization for 27 MeV-U Xe{35+} incident transmitted in (110) Si channels. International Conference On Atomic Collisions In Solids. 13, Aug 1989, Aarhus, Denmark. pp.145-155. ⟨in2p3-00013251⟩
  • J.-C. Poizat, S. Andriamonje, R. Anne, N.V. De Castro Faria, M. Chevallier, et al.. Heavy ion channeling in crystals. International Symposium On Swift Heavy Ions In Matter, Shim 89 1, May 1989, Caen, France. pp.71-75. ⟨in2p3-00004209⟩
  • S. Andriamonje, R. Anne, N.V. De Castro Faria, M. Chevallier, C. Cohen, et al.. Experimental aspects of S.H.C. (Swift Heavy ion Channeling). International Symposium On Swift Heavy Ions In Matter, Shim 89 1, May 1989, Caen, France. pp.167-169. ⟨in2p3-00004208⟩
  • P. Decowski, P. Box, K.A. Griffioen, E. Gierlik, R. Kamermans, et al.. Heavy ion interactions at fermi velocity. Zakopane School on Physics, Apr 1989, Zakopane, Poland. pp.110-128. ⟨in2p3-00013363⟩
  • P. Taskinen, D. Rolando-Eugio, J. Aysto, R. Béraud, J. Blachot, et al.. Production of neutron-rich nuclei in heavy ion induced fission. Zakopane School on Physics.24, Apr 1989, Zakopane, Poland. pp.314-316. ⟨in2p3-00002029⟩
  • I. Deloncle, K. Bencheikh, L. Bennour, M. Brack, J. Libert, et al.. A microscopic description of low-energy collective dynamics of even even nuclei. Session d'Etudes Biennale de Physique Nucleaire 10, Mar 1989, Aussois, France. pp.18.1-18.16. ⟨in2p3-00014542⟩

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