Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J.-P. Burq. Physique a Lep: les premiers resultats. Sondes Electromagnetiques et Faibles en Physique Nucleaires Entretiens du Centre Jacques Cartier 3, Dec 1989, Lyon, France. pp.127-135. ⟨in2p3-00023118⟩
  • M. Ericson. Nucleon size in the nucleus and pionic swelling. Sondes Electromagnetiques Et Faibles En Physique Nucleaires, Entretiens Du Centre Jacques Cartier 3, Dec 1989, Lyon, France. pp.139-150. ⟨in2p3-00002195⟩
  • C.J. Mchargue, P.S. Sklad, P. Angelini, C.W. White, J.C. Mccallum, et al.. Structure of amorphous Al2O3 produced by ion implantation. Materials Research Symposium 157, Nov 1989, Boston, United States. pp.505-512. ⟨in2p3-00013260⟩
  • M.C. Abreu, C. Baglin, A. Baldisseri, A. Baldit, G.P. Barreira, et al.. J/\psi production in collisions of proton oxygen and sulfur ions on heavy targets at 200 GeV per nucleon. French-Japonese Symposium On Nuclear Physics 5, Sep 1989, Dogashima, Japan. pp.23-32. ⟨in2p3-00007755⟩
  • P. Bonche, S.J. Krieger, P. Quentin, M.S. Weiss, J. Meyer, et al.. Etats isomeriques superdeformes a spin nul. Congres de la Societe Francaise de Physique, Sep 1989, Lyon, France. pp.45. ⟨in2p3-00015082⟩
  • P. Bonche, J. Dobaczewski, H. Flocard, S.J. Krieger, P.H. Heenen, et al.. Stabilite des isomeres de grande deformation des isotopes du mercure. Congres De La Societe Francaise De Physique, Sep 1989, Lyon, France. pp.45. ⟨in2p3-00004095⟩
  • Y. Jugnet, J.L. Droulas, Duc Tran Minh, A. Pouchelon. Chemical bonding and morphology of interfaces in aluminized silicones from evaporation and sputtering. International Conference On Metallization Of Polymers, Sep 1989, Montreal, Canada. pp.469-484. ⟨in2p3-00013259⟩
  • M. Ericson. La taille du nucléon dans le noyau et l'effet EMC. École thématique. Ecole Joliot Curie "Nucléons dans le noyau, mais encore..", Maubuisson, (France), du 11-15 septembre 1989 : 8ème session, 1989. ⟨cel-00647431⟩
  • J. Delorme. Delta dans les noyaux : aspects théoriques. École thématique. Ecole Joliot Curie "Nucléons dans le noyau, mais encore..", Maubuisson, (France), du 11-15 septembre 1989 : 8ème session, 1989. ⟨cel-00647439⟩
  • G. Marest, C. Donnet, N. Moncoffre, J. Tousset. Thermal evolution of high dose iron implanted sintered alumina. International Conference On The Application Of The Mossbauer Effect, Sep 1989, Budapest, Hungary. pp.1613-1620. ⟨in2p3-00013264⟩

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