Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • Feriel Khellaf, Nils Krah, Ilaria Rinaldi, Jean Michel Létang, Simon Rit. Monte Carlo simulation of the most likely path of protons through a transverse heterogeneity. IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Nov 2018, Sydney, Australia. ⟨hal-02330901⟩
    • D. Sarrut, Nils Krah, J N Badel, Jean Michel Létang. Learning SPECT detector response for Monte-Carlo simulations. Third Geant4 International User Conference, Oct 2018, Bordeaux, France. ⟨hal-01926625⟩
    • W. B. Li, A. Belchior, Michael Beuve, M.U. Bug, S. Di Maria, et al.. Comparison of Monte Carlo simulated physical radiation quantities for gold nanoparticles irradiated by x-rays and assessment of potential indication for targeted breast cancer treatment. Third Geant4 International User Conference, Oct 2018, Bordeaux, France. ⟨hal-02050756⟩
    • A. Etxebeste, Y. Feng, Jean Michel Létang, Voichita Maxim, Etienne Testa, et al.. An extension of the GATE Monte Carlo simulation toolkit to model Compton Camera systems. Third Geant4 International User Conference, Oct 2018, Bordeaux, France. ⟨hal-01926614⟩
    • Emeline Queguiner. Analysis of the data of the EDELWEISS-LT experiment searching for low-mass WIMP. Cosmology and Extra-Galactic Astrophysics [astro-ph.CO]. Université de Lyon, 2018. English. ⟨NNT : 2018LYSE1196⟩. ⟨tel-02025002⟩
    • Alexandra Dupuy. Du HI radio à la mesure de la croissance des bassins gravitationnels. Astrophysique [astro-ph]. Université de Lyon, 2018. Français. ⟨NNT : 2018LYSE1201⟩. ⟨tel-02108079v2⟩
    • D. Autiero. The long-standing experimental effort on the study of neutrino oscillations and the DUNE experiment. Ecole Internationale de Physique Subatomique (EIPS), Oct 2018, Lyon, France. ⟨in2p3-02106856⟩
    • O. Khalidova, S. Aghion, C. Amsler, M. Antonello, A. Belov, et al.. The AEgIS experiment: towards antimatter gravity measurements. 4th International Conference on Particle Physics and Astrophysics, Oct 2018, Moscow, Russia. pp.012104, ⟨10.1088/1742-6596/1390/1/012104⟩. ⟨hal-02416909⟩
    • C. Panetier, Y. Pipon, C. Gaillard, N. Moncoffre, L. Sarrasin, et al.. Thermal migration of Cs and Mo in UO_2 and UO_{2+x}. Numat 2018, Oct 2018, Seattle, United States. ⟨in2p3-02097725⟩
    • N. Galy, N. Moncoffre, N Toulhoat, N. Bérerd, Y Pipon, et al.. In situ Raman spectroscopy for characterization of ion induced defects in model graphite. Numat 2018, Oct 2018, Seattle, United States. ⟨in2p3-02097721⟩

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