Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • B. Adeva, O. Adriani, M. Aguilar-Benitez, H. Akbari, J. Alcaraz, et al.. A search for heavy charged and neutral leptons from Z^0 decays. Physics Letters B, 1990, 251, pp.321-330. ⟨10.1016/0370-2693(90)90943-Z⟩. ⟨in2p3-00005315⟩
  • B. Adeva, O. Adriani, M. Aguilar-Benitez, H. Akbari, J. Alcaraz, et al.. Search for neutral Higgs boson in Z^0 decay. Physics Letters B, 1990, 248, pp.203-210. ⟨10.1016/0370-2693(90)90040-D⟩. ⟨in2p3-00002548⟩
  • B. Adeva, O. Adriani, M. Aguilar-Benitez, H. Akbari, J. Alcaraz, et al.. Measurement of Z^0 \rightarrow b\bar{b} decay properties. Physics Letters B, 1990, 241, pp.416-424. ⟨in2p3-00014651⟩
  • B. Adeva, O. Adriani, M. Aguilar-Benitez, H. Akbari, J. Alcaraz, et al.. A test of QCD based on 4-jet events from Z^0 decays. Physics Letters B, 1990, 248, pp.227-234. ⟨10.1016/0370-2693(90)90043-6⟩. ⟨in2p3-00004335⟩
  • B. Adeva, O. Adriani, M. Aguilar-Benitez, H. Akbari, J. Alcaraz, et al.. Measurement of Z^0 \rightarrow b\bar{b} forward-backward asymmetry. Physics Letters B, 1990, 252, pp.713-721. ⟨in2p3-00018208⟩
  • C. Baglin, A. Baldisseri, A. Bussiere, J.P. Guillaud, R. Kossakowski, et al.. Transverse energy distributions in nucleus-nucleus collisions at 200 GeV/nucleon. Physics Letters B, 1990, 251, pp.472-476. ⟨in2p3-00003663⟩
  • M. El Bouanani. Caracterisation et modification de l'interface Nb-Cu de cavites supraconductrices par faisceaux d'ions. Chemical Physics [physics.chem-ph]. Université Claude Bernard - Lyon I, 1990. English. ⟨NNT : ⟩. ⟨in2p3-00009650⟩
  • R. Saoudi. Proprietes physicochimiques de films minces d'oxydes et d'oxynitrures de silicium et structure microscopique des interfaces SiO_2/Si(100) SiO_xN_y/Si(100). Université Claude Bernard - Lyon I, 1990. English. ⟨NNT : ⟩. ⟨in2p3-00013291⟩
  • B. Cheynis, B. Chambon, D. Drain, C. Pastor, D. Heuer, et al.. Evidence for an absorption effect in neutron emission in the ^{20}Ne + ^{58}Ni reaction at 30 MeV per nucleon. Zeitschrift für Physik. A, Atoms and Nuclei, 1990, 335, pp.77-85. ⟨10.1007/BF01289350⟩. ⟨in2p3-00013249⟩
  • P. Gerard, E. Lacroix, G. Marest, M. Dupuy, G. Rolland, et al.. Annealing effect on the properties of crystalline barium hexaferrite films. Journal of Magnetism and Magnetic Materials, 1990, 83, pp.13-14. ⟨10.1016/0304-8853(90)90412-J⟩. ⟨in2p3-00013244⟩

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