Health

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

SAADE Gaëlle

8786 documents

F. Perrot-Kunne, R. Bertini, M. Costa, H. Catz, A. Chaumeaux, et al.. Measurement of the analyzing power in $\bar p$ p elastic scattering between 439 and 697 MeV/c. Biennal Conference on Low Energy Antiproton Physics 1, Jul 1990, Stockholm, Sweden. ⟨in2p3-00007781⟩
A. Giorni, A. Lleres, P. Desesquelles, A.J. Cole, H. El Hage, et al.. Azimuthal angle correlations for alpha particle emission in the reaction $^{40}$ Ar + $^{(nat)}$ Cu at 25 MeV/nucleon. International Workshop On Particle Correlations And Interferometry In Nuclear Collisions,Corinne 90, Jun 1990, Nantes, France. pp.437-441. ⟨in2p3-00013347⟩
G. Chanfray, Z. Aouissat, P. Schuck, W. Noerenberg. $\sigma$ and $\rho$ meson strength distributions from in medium corrected $\pi-\pi$ correlations and the nuclear equation of state. International Workshop on Particle Correlations and Interferometry in Nuclear Collisions, Jun 1990, Nantes, France. pp.329-338. ⟨in2p3-00004230⟩
Khalid Bellafrouh. Etude théorique des multiplets de spin de quelques ions 3D dans des matrices oxydes et fluorures. Physique Nucléaire Expérimentale [nucl-ex]. Université Claude Bernard - Lyon I, 1990. Français. ⟨NNT : ⟩. ⟨tel-00747434⟩
L. Peralta, C. Baglin, A. Baldisseri, A. Bussiere, J.P. Guillaud, et al.. Meson production in oxygen-uranium and sulfur-uranium collisions at 200 GeV/nucleon. International Conference On Ultrarelativistic Nucleus-Nucleus Collision - Quark Matter '90 8, May 1990, Menton, France. pp.665C-668C. ⟨in2p3-00002543⟩
C. Baglin, A. Baldisseri, A. Bussiere, J.P. Guillaud, R. Kossakowski, et al.. The production of $\rho$ $\omega$ $\psi$ in 200 GeV/n S-U and O-U interactions. International Conference On Ultrarelativistic Nucleus-Nucleus Collisions - Quark Matter '90 8, May 1990, Menton, France. pp.449cC-453cC. ⟨in2p3-00003659⟩
M.C. Abreu, M. Alimi, C. Baglin, A. Baldisseri, M. Bedjidian, et al.. Transverse momentum of dimuons produced in p-U O-U and S-U collisions at 200 GeV/nucleon. International Conference On Ultrarelativistic Nucleus-Nucleus Collisions - Quark Matter '90 8, May 1990, Menton, France. pp.469. ⟨in2p3-00002545⟩
A. Devaux, C. Baglin, A. Baldisseri, A. Bussiere, J.P. Guillaud, et al.. Transverse energy spectra in nucleus nucleus collisions at 200 GeV/nucleon. International Conference On Ultrarelativistic Nucleus-Nucleus Collisions - Quark Matter '90 8, May 1990, Menton, France. pp.465C-468C. ⟨in2p3-00003654⟩
G. Chanfray, P. Schuck, W. Noerenberg. In medium corrected pion-pion correlations and the nuclear equation of state. International Workshop on Nuclear Dynamics, Apr 1990, Marciana Marina, Italy. pp.311-320. ⟨in2p3-00002191⟩
P.F. Box, T.M.V. Bootsma, C. Twenhoefel, P. Decowski, G.J. Van Nieuwenhuizen, et al.. Complex fragment emission in $^{28}$ Si + $^{nat}$ Si. Spring Meeting on Nuclear Physics Sections of the DPG, Mar 1990, Strasbourg, France. pp.1404-(A2.2). ⟨in2p3-00007227⟩

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