Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    8768 documents

    • P.F. Box, T.M.V. Bootsma, C. Twenhoefel, P. Decowski, G.J. Van Nieuwenhuizen, et al.. Complex fragment emission in ^{28}Si + ^{nat}Si. Spring Meeting on Nuclear Physics Sections of the DPG, Mar 1990, Strasbourg, France. pp.1404-(A2.2). ⟨in2p3-00007227⟩
    • M.C. Abreu, M. Alimi, C. Baglin, M. Bedjidian, P. Bordalo, et al.. Transverse energy production in O-Cu O-U and S-U interactions at 200 GeV per nucleon. Rencontres de Moriond 25, Mar 1990, Les Arcs, France. ⟨in2p3-00007782⟩
    • M.C. Abreu, C. Baglin, A. Baldisseri, A. Baldit, M. Bedjidian, et al.. \omega \rho and \phi production in P+U O+U and S+U collisions at 200 GeV/c. Rencontre De Moriond 25, Mar 1990, Les Arcs, France. pp.493-498. ⟨in2p3-00004124⟩
    • B. Canut, Laurence Romana, P. Thevenard, N. Moncoffre. Lattice disorder in α-Al2O3 induced by niobium implantation. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1990, 46 (1-4), pp.128 - 132. ⟨10.1016/0168-583X(90)90683-L⟩. ⟨hal-01685821⟩
    • P. Decowski, F. Altena, P.F. Box, E. Gierlik, K.A. Griffioen, et al.. Saturation effects in the fusion of ^{28}Si nuclei at bombarding energies between 20 and 35 MeV/nucleon. International Winter Meeting On Nuclear Physics 28, Jan 1990, Bormio, Italy. pp.368-380. ⟨in2p3-00013364⟩
    • B. Adeva, O. Adriani, M. Aguilar-Benitez, H. Akbari, J. Alcaraz, et al.. A measurement of the Z0 leptonic partial widths and the vector and axial vector coupling constants. Physics Letters B, 1990, 238, pp.122-130. ⟨10.1016/0370-2693(90)92111-U⟩. ⟨in2p3-00018205⟩
    • M. Ericson, H. Bando. A consistent treatment of medium effects on hypernuclear pi-mesonic decay. Physics Letters B, 1990, 237, pp.169-174. ⟨in2p3-00000425⟩
    • J-P. Ader, F. Gieres. Topological super YM and super Donaldson polynomials. Zeitschrift für Physik. C, Particles and Fields, 1990, 46, pp.285-291. ⟨in2p3-00002489⟩
    • Y. Tahri, H. Chermette, N. El Khatib, J.C. Krupa, E. Simoni. Electronic structures of thorium and protactinium halide clusters of {thx(inf8)}(sup4-) type. Journal of the Less Common Metals, 1990, 158, pp.105-116. ⟨in2p3-00012947⟩
    • C.J. Mchargue, P.S. Sklad, J.C. Mccallum, C.W. White, A. Perez, et al.. The effects of annealing on the structure and distribution of charge states of iron implanted into \alpha-Al_2O_3 at 77K. Materials Research Society Symposia Proceedings, 1990, 157, pp.555-560. ⟨in2p3-00013261⟩

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