Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Farvah Mahmoudi. Dark matter, collider searches and the early Universe. 5th Biennial Workshop on Discovery Physics at the LHC, Dec 2018, Hazyview, South Africa. pp.012020, ⟨10.1088/1742-6596/1271/1/012020⟩. ⟨hal-02290752⟩
  • Giacomo Cacciapaglia, Teng Ma, Yongcheng Wu. Composite Models on a safe road to the Planck scale. 5th Biennial Workshop on Discovery Physics at the LHC, Dec 2018, Hazyview, South Africa. pp.012014, ⟨10.1088/1742-6596/1271/1/012014⟩. ⟨hal-02290753⟩
  • Aldo Deandrea. Unification of gauge and Yukawa couplings. 5th Biennial Workshop on Discovery Physics at the LHC, Dec 2018, Hazyview, South Africa. pp.012016, ⟨10.1088/1742-6596/1271/1/012016⟩. ⟨hal-02290789⟩
  • L. Feketeová, F. Berthias, H. Abdoul-Carime, Florent Calvo, B. Farizon, et al.. Velocity distribution of molecules evaporated from H+(H2O)4. Réunion Plénière GDR EMIE (Edifices Moléculaires Isolés et Environnés), Nov 2018, Nouan-le-Fuzelier, France. ⟨in2p3-02098171⟩
  • X. Artru, Z. Belghobsi. Quark polarimetry with a recursive fragmentation model including the spin degree of freedom. 1st Sharjah International Conference on Particle Physics, Astrophysics and Cosmology, Nov 2018, Sharjah, United Arab Emirates. pp.012003, ⟨10.1088/1742-6596/1258/1/012003⟩. ⟨hal-02394729⟩
  • Feriel Khellaf, Nils Krah, Ilaria Rinaldi, Jean Michel Létang, Simon Rit. Monte Carlo simulation of the most likely path of protons through a transverse heterogeneity. IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Nov 2018, Sydney, Australia. ⟨hal-02330901⟩
  • D. Sarrut, Nils Krah, J N Badel, Jean Michel Létang. Learning SPECT detector response for Monte-Carlo simulations. Third Geant4 International User Conference, Oct 2018, Bordeaux, France. ⟨hal-01926625⟩
  • W. B. Li, A. Belchior, Michael Beuve, M.U. Bug, S. Di Maria, et al.. Comparison of Monte Carlo simulated physical radiation quantities for gold nanoparticles irradiated by x-rays and assessment of potential indication for targeted breast cancer treatment. Third Geant4 International User Conference, Oct 2018, Bordeaux, France. ⟨hal-02050756⟩
  • A. Etxebeste, Y. Feng, Jean Michel Létang, Voichita Maxim, Etienne Testa, et al.. An extension of the GATE Monte Carlo simulation toolkit to model Compton Camera systems. Third Geant4 International User Conference, Oct 2018, Bordeaux, France. ⟨hal-01926614⟩
  • Alexandra Dupuy. Du HI radio à la mesure de la croissance des bassins gravitationnels. Astrophysique [astro-ph]. Université de Lyon, 2018. Français. ⟨NNT : 2018LYSE1201⟩. ⟨tel-02108079v2⟩

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