Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8788 documents

  • Jayde Livingstone, Denis Dauvergne, A. Etxebeste, Mattia Fontana, Marie-Laure Gallin-Martel, et al.. Influence of sub-nanosecond time of flight resolution for online range verification in proton therapy using the line-cone reconstruction in Compton imaging. Physics in Medicine and Biology, 2021, 66, pp.125012. ⟨10.1088/1361-6560/ac03cb⟩. ⟨hal-03257804⟩
  • Franck Rabilloud, Janina Kopyra, Hassan Abdoul-Carime. Fragmentation of Nickel(II) and Cobalt(II) Bis(acetylacetonate) Complexes Induced by Slow (<10 eV) Electrons. Inorganic Chemistry, 2021, 60 (11), pp.8154-8163. ⟨10.1021/acs.inorgchem.1c00795⟩. ⟨hal-03281474⟩
  • RaphaĂ«lle Demeyer, JĂ©rĂ´me Margueron. Comment des pĂ©dagogies alternatives peuvent aider Ă  la rĂ©ussite des Ă©tudiants de physique du 1 er cycle universitaire. Reflets de la Physique, 2021, 69, pp.34-38. ⟨10.1051/refdp/202169034⟩. ⟨in2p3-03450405⟩
  • H. Rabus, W.B. Li, C. Villagrasa, J. Schuemann, P.A. Hepperle, et al.. Intercomparison of Monte Carlo calculated dose enhancement ratios for gold nanoparticles irradiated by X-rays: Assessing the uncertainty and correct methodology for extended beams. Physica Medica European Journal of Medical Physics, 2021, 84, pp.241-253. ⟨10.1016/j.ejmp.2021.03.005⟩. ⟨hal-03257934⟩
  • Camille Camen. Recherche d'un second boson de Higgs de masse mH < 110 GeV dans le canal di-photon au sein de l’expĂ©rience CMS au LHC. Physique des accĂ©lĂ©rateurs [physics.acc-ph]. UniversitĂ© de Lyon, 2021. Français. ⟨NNT : 2021LYSE1034⟩. ⟨tel-03635680⟩
  • Floriane Poignant, Hela Charfi, Chen-Hui Chan, Elise Dumont, David Loffreda, et al.. Monte Carlo simulation of free radical production under keV photon irradiation of gold nanoparticle aqueous solution. Part II: Local primary chemical boost. Radiation Physics and Chemistry, 2021, 179, pp.109161. ⟨10.1016/j.radphyschem.2020.109161⟩. ⟨hal-03029595⟩
  • M.-L. Gallin-Martel, S. Curtoni, S. Marcatili, L. Abbassi, A. Bes, et al.. X-ray beam induced current analysis of CVD diamond detectors in the perspective of a beam tagging hodoscope development for hadrontherapy on-line monitoring. Diamond and Related Materials, 2021, 112, pp.108236. ⟨10.1016/j.diamond.2020.108236⟩. ⟨hal-03150914⟩
  • Wafa Bouleftour, Benoite Mery, Elise Rowinski, Charlene Rivier, Elisabeth Daguenet, et al.. Cardio-Oncology Preclinical Models: A Comprehensive Review. Anticancer Research, 2021, 41 (11), pp.5355-5364. ⟨10.21873/anticanres.15348⟩. ⟨hal-03463909⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, et al.. Search for dark matter produced in association with a leptonically decaying Z boson in proton-proton collisions at \sqrt{s} = 13 TeV. Eur.Phys.J.C, 2021, 81 (1), pp.13. ⟨10.1140/epjc/s10052-020-08739-5⟩. ⟨hal-02934005⟩
  • Armen Tumasyan, Wolfgang Adam, Janik Walter Andrejkovic, Thomas Bergauer, Suman Chatterjee, et al.. Search for Long-Lived Particles Decaying in the CMS End Cap Muon Detectors in Proton-Proton Collisions at \sqrt s =13  TeV. Phys.Rev.Lett., 2021, 127 (26), pp.261804. ⟨10.1103/PhysRevLett.127.261804⟩. ⟨hal-03312916⟩

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