Health (PRISME)

  • Presentation
  • Activities
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  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
393 documents

  • G. Muggiolu, S. Libert, B. Treillard, G. Alfonse, P. Philouze, et al.. PO-1929 Identification of DNA repair-based biomarkers related to treatment outcome in head and neck cancers. ESTRO, Aug 2021, Madrid, Spain. pp.S1643-S1644, ⟨10.1016/s0167-8140(21)08380-8⟩. ⟨hal-03450014⟩
  • Anne-Sophie Wozny, Arnaud Gauthier, Gersende Alphonse, Céline Malésys, Virginie Varoclier, et al.. Involvement of HIF-1α in the Detection, Signaling, and Repair of DNA Double-Strand Breaks after Photon and Carbon-Ion Irradiation. Cancers, 2021, 13 (15), pp.3833. ⟨10.3390/cancers13153833⟩. ⟨hal-03326508⟩
  • Jean-Baptiste Guy, Sophie Espenel, Safa Louati, Arnaud Gauthier, Max-Adrien Garcia, et al.. Combining radiation to EGFR and Bcl-2 blockade: a new approach to target cancer stem cells in head and neck squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology, 2021, 147 (7), pp.1905-1916. ⟨10.1007/s00432-021-03593-8⟩. ⟨hal-03258241⟩
  • Jayde Livingstone, Denis Dauvergne, A. Etxebeste, Mattia Fontana, Marie-Laure Gallin-Martel, et al.. Influence of sub-nanosecond time of flight resolution for online range verification in proton therapy using the line-cone reconstruction in Compton imaging. Physics in Medicine and Biology, 2021, 66, pp.125012. ⟨10.1088/1361-6560/ac03cb⟩. ⟨hal-03257804⟩
  • Franck Rabilloud, Janina Kopyra, Hassan Abdoul-Carime. Fragmentation of Nickel(II) and Cobalt(II) Bis(acetylacetonate) Complexes Induced by Slow (<10 eV) Electrons. Inorganic Chemistry, 2021, 60 (11), pp.8154-8163. ⟨10.1021/acs.inorgchem.1c00795⟩. ⟨hal-03281474⟩
  • H. Rabus, W.B. Li, C. Villagrasa, J. Schuemann, P.A. Hepperle, et al.. Intercomparison of Monte Carlo calculated dose enhancement ratios for gold nanoparticles irradiated by X-rays: Assessing the uncertainty and correct methodology for extended beams. Physica Medica European Journal of Medical Physics, 2021, 84, pp.241-253. ⟨10.1016/j.ejmp.2021.03.005⟩. ⟨hal-03257934⟩
  • Floriane Poignant, Hela Charfi, Chen-Hui Chan, Elise Dumont, David Loffreda, et al.. Monte Carlo simulation of free radical production under keV photon irradiation of gold nanoparticle aqueous solution. Part II: Local primary chemical boost. Radiation Physics and Chemistry, 2021, 179, pp.109161. ⟨10.1016/j.radphyschem.2020.109161⟩. ⟨hal-03029595⟩
  • M.-L. Gallin-Martel, S. Curtoni, S. Marcatili, Latifa Abbassi, A. Bes, et al.. X-ray beam induced current analysis of CVD diamond detectors in the perspective of a beam tagging hodoscope development for hadrontherapy on-line monitoring. Diamond and Related Materials, 2021, 112, pp.108236. ⟨10.1016/j.diamond.2020.108236⟩. ⟨hal-03150914⟩
  • Oreste Allegrini, J. P. Cachemiche, C.P.C. Caplan, Bruno Carlus, Xiushan Chen, et al.. Characterization of a beam-tagging hodoscope for hadrontherapy monitoring. Journal of Instrumentation, 2021, 16, pp.P02028. ⟨10.1088/1748-0221/16/02/P02028⟩. ⟨hal-03103624⟩
  • Verónica Belén Tessaro, Benoit Gervais, Floriane Poignant, Michael Beuve, Mariel Elisa Galassi. Monte Carlo transport of swift protons and light ions in water: The influence of excitation cross sections, relativistic effects, and Auger electron emission in w-values. Physica Medica European Journal of Medical Physics, 2021, 88, pp.71-85. ⟨10.1016/j.ejmp.2021.06.006⟩. ⟨hal-03335777⟩

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